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The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.

Journal article
Authors Niklas Mattsson
Ulf Andreasson
Staffan Persson
Hiroyuki Arai
Sat Dev Batish
Sergio Bernardini
Luisella Bocchio-Chiavetto
Marinus A Blankenstein
Maria C Carrillo
Sonia Chalbot
Els Coart
Davide Chiasserini
Neal Cutler
Gunilla Dahlfors
Stefan Duller
Anne M Fagan
Orestes Forlenza
Giovanni B Frisoni
Douglas Galasko
Daniela Galimberti
Harald Hampel
Aase Handberg
Michael T Heneka
Adrianna Z Herskovits
Sanna-Kaisa Herukka
David M Holtzman
Christian Humpel
Bradley T Hyman
Khalid Iqbal
Mathias Jucker
Stephan A Kaeser
Elmar Kaiser
Elisabeth Kapaki
Daniel Kidd
Peter Klivenyi
Cindy S Knudsen
Markus P Kummer
James Lui
Albert Lladó
Piotr Lewczuk
Qiao-Xin Li
Ralph Martins
Colin Masters
John McAuliffe
Marc Mercken
Abhay Moghekar
José Luis Molinuevo
Thomas J Montine
William Nowatzke
Richard O'Brien
Markus Otto
George P Paraskevas
Lucilla Parnetti
Ronald C Petersen
David Prvulovic
Herman P M de Reus
Robert A Rissman
Elio Scarpini
Alessandro Stefani
Hilkka Soininen
Johannes Schröder
Leslie M Shaw
Anders Skinningsrud
Brith Skrogstad
Annette Spreer
Leda Talib
Charlotte Teunissen
John Q Trojanowski
Hayrettin Tumani
Robert M Umek
Bianca Van Broeck
Hugo Vanderstichele
Laszlo Vecsei
Marcel M Verbeek
Manfred Windisch
Jing Zhang
Henrik Zetterberg
Kaj Blennow
Published in Alzheimer's & dementia : the journal of the Alzheimer's Association
Volume 7
Issue 4
Pages 386-395.e6
ISSN 1552-5279
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 386-395.e6
Language en
Links dx.doi.org/10.1016/j.jalz.2011.05.2...
Subject categories Psychiatry

Abstract

The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The Alzheimer's Association has initiated a global quality control program to estimate and monitor variability of measurements, quantify batch-to-batch assay variations, and identify sources of variability. In this article, we present the results from the first two rounds of the program.

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