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Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland

Journal article
Authors Hülya Çevik Aras
Jörgen Ekström
Published in ORAL DISEASES
Volume 16
Issue 7
Pages 661-667
ISSN 1354-523X
Publication year 2010
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 661-667
Language en
Links dx.doi.org/10.1111/j.1601-0825.2010...
Keywords oxidative stress, nitric-oxide, neutrophil content, lipopolysaccharide, salivary, inflammation, myeloperoxidase, prostaglandins, dysfunction, secretion
Subject categories Pharmacological research

Abstract

OBJECTIVE:To define the influence of cholecystokinin and melatonin on the inflammatory response of the lipopolysaccharide-exposed rat parotid gland. MATERIALS AND METHODS: Bacterial lipopolysaccharide was infused retrogradely into the parotid duct. The degree of inflammation three hours postadministration was estimated from the activity of myeloperoxidase, reflecting glandular neutrophil infiltration. RESULTS: The myeloperoxidase activity of the lipopolysaccharide-exposed gland was 10-fold greater than that of the contralateral gland. Combined with sulphated cholecystokinin-8 (10 or 25 μg kg(-1) , given twice intraperitoneally) or melatonin (10 or 25 mg kg(-1) x 2) the lipopolysaccharide-induced response was elevated 4.6- and 3.5-folds at the most. The cholecystokinin-A receptor antagonist lorglumide reduced the inhibitory effect of cholecystokinin-8, while the melatonin 2-preferring receptor antagonist luzindole had no effect on the melatonin-induced inhibition. Unselective nitric oxide-synthase inhibition abolished the increase in myeloperoxidase activity, whereas inhibition of inducible or neuronal nitric oxide-synthase (of non-nervous origin) halved the inflammatory response. CONCLUSION: Some hormones may contribute to anti-inflammatory action in salivary glands in physiological conditions. They are potential pharmacological tools for treating gland inflammation. The inflammation, as judged from the myeloperoxidase activity, was entirely dependent on nitric oxide-synthase activity, indicating that the hormones directly or indirectly reduced the generation of nitric oxide.

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