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Development of gut-homing receptors on circulating B cells during infancy.

Journal article
Authors Anna-Carin Andersson Lundell
Hardis Rabe
Marianne Quiding-Järbrink
Kerstin Andersson
Inger Nordström
Ingegerd Adlerberth
Agnes E Wold
Anna Rudin
Published in Clinical immunology
Volume 138
Issue 1
Pages 97-106
ISSN 1521-7035
Publication year 2011
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Biomedicine, Department of Infectious Medicine
Pages 97-106
Language en
Links dx.doi.org/10.1016/j.clim.2010.10.0...
Keywords Infants; B cells; Gut-homing receptors
Subject categories Immunology in the medical area

Abstract

B cell gut-homing is mainly mediated by α4β7, CCR9 and CCR10. We here studied the expression of these receptors on B cells from cord blood and from peripheral blood at 1, 4, 18 and 36months of age in a prospective cohort of Swedish infants. The proportion of all B cells expressing α4β7 as well as the fraction of CCR10+ B cells expressing α4β7 was highest in early infancy. Nearly all naïve B cells in all age groups expressed α4β7, whereas the expression on class-switched B cells decreased with age. Moreover, the proportion of both IgA+ and IgG+ B cells expressing α4β7, CCR9 and CCR10 were higher during the first months when compared to adults. In conclusion, the high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 and CCR10 in the first months of life indicates activation of naïve B cells in the gut, coinciding with bacterial colonization.

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