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Reactive glial cells: increased stiffness correlates with increased intermediate filament expression.

Journal article
Authors Yun-Bi Lu
Ianors Iandiev
Margrit Hollborn
Nicole Körber
Elke Ulbricht
Petra G Hirrlinger
Thomas Pannicke
Er-Qing Wei
Andreas Bringmann
Hartwig Wolburg
Ulrika Wilhelmsson
Milos Pekny
Peter Wiedemann
Andreas Reichenbach
Josef A Käs
Published in The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume 25
Issue 2
Pages 624-31
ISSN 1530-6860
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 624-31
Language en
Subject categories Medical and Health Sciences


Increased stiffness of reactive glial cells may impede neurite growth and contribute to the poor regenerative capabilities of the mammalian central nervous system. We induced reactive gliosis in rodent retina by ischemia-reperfusion and assessed intermediate filament (IF) expression and the viscoelastic properties of dissociated single glial cells in wild-type mice, mice lacking glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)) in which glial cells are consequently devoid of IFs, and normal Long-Evans rats. In response to ischemia-reperfusion, glial cells stiffened significantly in wild-type mice and rats but were unchanged in GFAP(-/-)Vim(-/-) mice. Cell stiffness (elastic modulus) correlated with the density of IFs. These results support the hypothesis that rigid glial scars impair nerve regeneration and that IFs are important determinants of cellular viscoelasticity in reactive glia. Thus, therapeutic suppression of IF up-regulation in reactive glial cells may facilitate neuroregeneration.-Lu, Y.-B., Iandiev, I., Hollborn, M., Körber, N., Ulbricht, E., Hirrlinger, P. G., Pannicke, T., Wei, E.-Q., Bringmann, A., Wolburg, H., Wilhelmsson, U., Pekny, M., Wiedemann, P., Reichenbach, A., Käs, J. A. Reactive glial cells: increased stiffness correlates with increased intermediate filament expression.

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