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Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.

Journal article
Authors S Lall
L Y Tung
Claes Ohlsson
John-Olov Jansson
Suzanne L. Dickson
Published in Biochemical and biophysical research communications
Volume 280
Issue 1
Pages 132-8
ISSN 0006-291X
Publication year 2001
Published at Institute of Internal Medicine, Dept of Medicine
Institute of Internal Medicine
Institute of Physiology and Pharmacology, Dept of Physiology
Pages 132-8
Language en
Links dx.doi.org/10.1006/bbrc.2000.4065
Keywords Adipose Tissue, anatomy & histology, drug effects, physiology, Animals, Body Weight, drug effects, Female, Growth Hormone, deficiency, genetics, pharmacology, physiology, Heterozygote, Hormones, pharmacology, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Oligopeptides, pharmacology, Weight Gain
Subject categories Medical and Health Sciences

Abstract

Growth hormone secretagogues (GHSs) stimulate growth hormone (GH) secretion, which is lipolytic. Here we compared the effects of twice daily s.c. treatment of GH and the GHS, ipamorelin, on body fat in GH-deficient (lit/lit) and in GH-intact (+/lit and +/+) mice. In +/lit and lit/lit mice ipamorelin induced a small (15%) increase in body weight by 2 weeks, that was not further augmented by 9 weeks. GH treatment markedly enhanced body weight in both groups. Ipamorelin also increased fat pad weights relative to body weight in both lit/lit and +/lit mice. Two weeks GHS treatment (ipamorelin or GHRP-6) also increased relative body fat, quantified by in vivo dual energy X-ray absorpiometry (DEXA) in GH-intact mice. GH decreased relative fat mass in lit/lit mice and had no effect in GH-intact mice. Treatment with GHS, but not GH, increased serum leptin and food intake in GH-intact mice. Thus, GHSs increase body fat by GH-independent mechanisms that may include increased feeding.

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