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microRNAs in asthma pathogenesis - from mouse to man

Review article
Authors Julie Weidner
Carina Malmhäll
Madeleine Rådinger
Published in Journal of Translational Genetics and Genomics
Volume 3
Issue 2
Publication year 2019
Published at Krefting Research Centre
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Language en
Links https://doi.org/10.20517/jtgg.2018....
https://jtggjournal.com/article/vie...
https://gup.ub.gu.se/file/207717
Keywords microRNA, asthma, allergy, animal models, human, endotype, biomarker, phenotype
Subject categories Cell and Molecular Biology, Respiratory Medicine and Allergy, Immunology

Abstract

Asthma is a heterogenic disease affecting over 300 million people of all ages and socioeconomic status worldwide. The disease is characterized by chronic airway inflammation, reversible airflow obstruction, wheeze, cough and shortness of breath. Although asthma has been traditionally described by phenotypes such as immune cell type or allergy, it is clear that a variety of subtypes have emerged, adding further complexity to the disease. microRNAs are small, non-coding RNAs that act as regulatory molecules, binding to one or several target mRNAs, often resulting in translational silencing. In recent years, microRNAs have been the subject of many studies in order to better understand the mechanisms driving asthma development as well as discovery of potential biomarkers for asthma. In this review, we focus on the emerging role of microRNAs in asthma, from animal models to human cohorts.

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Utskriftsdatum: 2019-08-22