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Salivary microbial profiles in 5-year old children with oral clefts: a comparative study

Journal article
Authors A. L. Sundell
C. Ullbro
Gunnar Dahlén
A. Marcusson
S. Twetman
Published in European Archives of Paediatric Dentistry
Volume 19
Issue 1
Pages 57-60
ISSN 1818-6300
Publication year 2018
Published at Institute of Odontology, Section 3
Pages 57-60
Language en
Keywords Salivary microflora, Caries, Oral hygiene, Cleft lip and palate, Children, lip and/or palate, dna-dna hybridization, dental-caries, bacteria, health, adolescents, prevalence, parameters, Dentistry, Oral Surgery & Medicine
Subject categories Dentistry


Aim To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study. Methods The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA-DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires. Results Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear. Conclusions The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria.

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Utskriftsdatum: 2019-09-17