To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Neuropathologic Assessmen… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Neuropathologic Assessment of Dementia Markers in Identical and Fraternal Twins

Journal article
Authors D. Iacono
I. Volkman
I. Nennesmo
N. L. Pedersen
L. Fratiglioni
Boo Johansson
D. Karlsson
B. Winblad
M. Gatz
Published in Brain Pathology
Volume 24
Issue 4
Pages 317-333
ISSN 1015-6305
Publication year 2014
Published at Department of Psychology
Pages 317-333
Language en
Links dx.doi.org/10.1111/bpa.12127
Keywords AD pathology, aging, ApoE, dementia, monozygotic and dizygotic twins, non-AD co-occurring brain
Subject categories Psychology, Neurology

Abstract

Twin studies are an incomparable source of investigation to shed light on genetic and non-genetic components of neurodegenerative diseases, as Alzheimer's disease (AD). Detailed clinicopathologic correlations using twin longitudinal data and post-mortem examinations are mostly missing. We describe clinical and pathologic findings of seven monozygotic (MZ) and dizygotic (DZ) twin pairs. Our findings show good agreement between clinical and pathologic diagnoses in the majority of the twin pairs, with greater neuropathologic concordance in MZ than DZ twins. Greater neuropathologic concordance was found for -amyloid than tau pathology within the pairs. ApoE4 was associated with higher -amyloid and earlier dementia onset, and importantly, higher frequency of other co-occurring brain pathologies, regardless of the zygosity. Dementia onset, dementia duration, difference between twins in age at dementia onset and at death, did not correlate with AD pathology. These clinicopathologic correlations of older identical and fraternal twins support the relevance of genetic factors in AD, but not their sufficiency to determine the pathology, and consequently the disease, even in monozygotic twins. It is the interaction among genetic and non-genetic risks which plays a major role in influencing, or probably determining, the degeneration of those brain circuits associated with pathology and cognitive deficits in AD.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
http://www.gu.se/english/research/publication/?languageId=100001&disableRedirect=true&returnUrl=http%3A%2F%2Fwww.gu.se%2Fforskning%2Fpublikation%2F%3Fprint%3Dtrue%26publicationId%3D200578&publicationId=200578
Utskriftsdatum: 2019-12-07