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Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?

Journal article
Authors Petra Suchankova
Jonas Klang
Carin Cavanna
Göran Holm
Staffan Nilsson
Erik G Jönsson
Agneta Ekman
Published in Journal of psychiatry & neuroscience : JPN
Volume 37
Issue 2
Pages 122-128
ISSN 1488-2434
Publication year 2012
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Medicine
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 122-128
Language en
Keywords Case-Control Studies, Cohort Studies, DNA, genetics, Female, Genotype, Humans, Male, Middle Aged, Nerve Growth Factors, genetics, Personality, genetics, Personality Tests, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Psychotic Disorders, psychology, Receptors, Immunologic, genetics, S100 Proteins, genetics, Schizophrenia, genetics, Schizophrenic Psychology
Subject categories Pharmacology


The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.

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