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Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

Journal article
Authors Michelle M Mielke
Jeremy A Syrjanen
Kaj Blennow
Henrik Zetterberg
Ingmar Skoog
Prashanthi Vemuri
Mary M Machulda
Jonathan Graff-Radford
David S Knopman
Clifford R Jack
Ronald C Petersen
Silke Kern
Published in Alzheimer's & dementia : the journal of the Alzheimer's Association
Volume 15
Issue 11
Pages 1437-1447
ISSN 1552-5279
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Centre for Ageing and Health (Agecap)
Pages 1437-1447
Language en
Subject categories Neurochemistry


Three cerebrospinal fluid (CSF) markers of neurodegeneration (N) (neurofilament light [NfL], total-tau [T-tau], and neurogranin [Ng]) have been proposed under the AT(N) scheme of the National Institute on Aging-Alzheimer's Association Research Framework.We examined, in a community-based population (N = 777, aged 50-95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays.Multiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T-tau had the strongest association with cognition in the presence of amyloidosis, followed by Ng. Variables associations with NfL did not differ by amyloid status.Understanding factors that influence CSF (N) markers will assist in the interpretation and utility of these markers in clinical practice.

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