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Profibrinolytic effect of the epigenetic modifier valproic Acid in man.

Journal article
Authors Ott Saluveer
Pia Larsson
Wilhelm Ridderstråle
Thordis Hrafnkelsdottir
Sverker Jern
Niklas Bergh
Published in PloS one
Volume 9
Issue 10
Pages e107582
ISSN 1932-6203
Publication year 2014
Published at Wallenberg Laboratory
Pages e107582
Language en
Subject categories Cardiovascular medicine


The aim of the study was to test if pharmacological intervention by valproic acid (VPA) treatment can modulate the fibrinolytic system in man, by means of increased acute release capacity of tissue plasminogen activator (t-PA) as well as an altered t-PA/Plasminogen activator inhibitor -1 (PAI-1) balance. Recent data from in vitro research demonstrate that the fibrinolytic system is epigenetically regulated mainly by histone deacetylase (HDAC) inhibitors. HDAC inhibitors, including VPA markedly upregulate t-PA gene expression in vitro.

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