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Extremely preterm birth in Sweden - clear progress but remaining challenges

Review article
Authors Thomas Abrahamsson
Henrik Hagberg
Magnus Domellöf
Baldvin Jonsson
Ann Hellström
Published in Läkartidningen
Volume 116
ISSN 1652-7518
Publication year 2019
Published at Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Language sv
Keywords Bronchopulmonary Dysplasia, epidemiology, physiopathology, prevention & control, Centralized Hospital Services, Cerebral Hemorrhage, diagnostic imaging, epidemiology, physiopathology, prevention & control, Cerebral Ventricles, blood supply, diagnostic imaging, Enterocolitis, Necrotizing, epidemiology, physiopathology, prevention & control, Female, Humans, Infant Nutritional Physiological Phenomena, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, epidemiology, physiopathology, prevention & control, Perinatal Care, organization & administration, Pregnancy, Premature Birth, mortality, Retinopathy of Prematurity, blood, epidemiology, physiopathology, prevention & control, Survival Rate, Sweden, epidemiology
Subject categories Pediatrics


The recently documented high survival of extremely preterm infants in Sweden is related to a high degree of centralization of pre- and postnatal care and to recently issued national consensus guidelines providing recommendations for perinatal care at 22-24 gestational weeks. The prevalence of major neonatal morbidity remains high and exceeded 60 % in a recent study of extremely preterm infants born at < 27 gestational weeks delivered in Sweden in 2014-2016 and surviving to 1 year of age. Damage to immature organ systems inflicted during the neonatal period causes varying degrees of functional impairment with lasting effects in the growing child. There is an urgent need for evidence-based novel interventions aiming to prevent neonatal morbidity with a subsequent improvement of long-term outcome.

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Utskriftsdatum: 2020-08-08