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Excess risk of hospitalisation for heart failure among people with type 2 diabetes

Journal article
Authors Annika Rosengren
Jon Edqvist
Araz Rawshani
N. Sattar
S. Franzen
Martin Adiels
A. M. Svensson
Marcus Lind
Soffia Gudbjörnsdottir
Published in Diabetologia
Volume 61
Issue 11
Pages 2300-09
ISSN 1432-0428
Publication year 2018
Published at Institute of Medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
Pages 2300-09
Language en
Keywords Albuminuria, HbA1c, Heart failure, Registries, Type 2 diabetes
Subject categories Clinical Medicine


AIMS/HYPOTHESIS: Type 2 diabetes is an established risk factor for heart failure, but age-specific data are sparse. We aimed to determine excess risk of heart failure, based on age, glycaemic control and kidney function in comparison with age- and sex-matched control individuals from the general population. METHODS: Individuals with type 2 diabetes registered in the Swedish National Diabetes Registry 1998-2012 (n = 266,305) were compared with age-, sex- and county-matched control individuals without diabetes (n = 1,323,504), and followed over a median of 5.6 years until 31 December 2013. RESULTS: We identified 266,305 individuals with type 2 diabetes (mean age 62.0 years, 45.3% women) and 1,323,504 control individuals. Of the individuals with type 2 diabetes and control individuals, 18,715 (7.0%) and 50,157 (3.8%) were hospitalised with a diagnosis of heart failure, respectively. Comparing individuals with diabetes with those in the control group, men and women with type 2 diabetes who were younger than 55 years of age had HRs for hospitalisation for heart failure of 2.07 (95% CI 1.73, 2.48) and 4.59 (95% CI 3.50, 6.02), respectively, using analyses adjusted for socioeconomic variables and associated conditions. Younger age, poorer glycaemic control and deteriorating renal function were all associated with increased excess risk of heart failure in those with type 2 diabetes compared with the control group. However, people with diabetes who were >/=75 years and without albuminuria or with good glycaemic control (HbA1c

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