To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Low serum levels of CCL5 … - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Contact form








 


Note! If you want an answer on a question you must specify your email address




Low serum levels of CCL5 are associated with longer duration of viral shedding in norovirus infection

Journal article
Authors Lars Gustavsson
Susann Skovbjerg
Magnus Lindh
Johan Westin
Lars-Magnus Andersson
Published in Journal of Clinical Virology
Volume 69
Pages 133-137
ISSN 1386-6532
Publication year 2015
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 133-137
Language en
Links dx.doi.org/10.1016/j.jcv.2015.06.08...
Keywords Norovirus, Cytokines, CCL5, Viral shedding, Viral load, T-CELLS, RECTAL SWABS, GASTROENTERITIS, RANTES, VIRUS, PCR, LYMPHOCYTES, ROTAVIRUS, MORBIDITY, PATHOGENS, Virology
Subject categories Virology

Abstract

Background: The mechanisms that determine the duration of fecal shedding of norovirus in humans have not been described in detail. Objectives: We investigated serum inflammatory mediator levels in relation to the duration of viral shedding in norovirus infection. Study design: A prospective cohort study of patients hospitalized with acute norovirus genogroup II infection. Rectal swab samples were obtained at inclusion and day 7, 14, 21 and 28. Serum levels of 42 inflammatory mediators were determined with a Luminex-based cytokine assay. Sera from 20 healthy blood donors served as controls. Results: Altogether, 28 patients (54% women, median age 83 years, median duration of symptoms 3 days) were included. Twelve subjects cleared the virus within 14 days and 16 were norovirus-RNA positive for >21 days, constituting the two study groups ("rapid" vs. "slow" clearance). Individuals with norovirus infection had higher levels of IL-18, CXCL9, CXCL10, soluble IL-2 receptor and macrophage migration inhibitory factor (MIF), compared to controls (p < 0.05), with the highest median concentrations in the slow clearance group. In contrast, CCL5 levels were lower in the slow compared to the rapid clearance group (median 54 vs. 134 ng/mL, p < 0.05), and lower in norovirus-infected patients than in controls. Conclusion: Low levels of CCL5 were associated with longer duration of viral shedding, suggesting that CCL5 may influence the clearance of norovirus. (C) 2015 Elsevier B.V. All rights reserved.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?