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Objective assessment of tumour response to therapy based on tumour growth kinetics.

Journal article
Authors Esmaeil Mehrara
Eva Forssell-Aronsson
Peter Bernhardt
Published in British journal of cancer
Volume 105
Issue 5
Pages 682-6
ISSN 1532-1827
Publication year 2011
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 682-6
Language en
Links dx.doi.org/10.1038/bjc.2011.276
Keywords Cell Growth Processes, Endpoint Determination, methods, Female, Humans, Kinetics, Magnetic Resonance Imaging, Male, Models, Theoretical, Neoplasms, diagnosis, pathology, therapy, Patient Care Planning, Positron-Emission Tomography, Prognosis, Treatment Outcome, Tumor Burden
Subject categories Cancer and Oncology, Radiological physics

Abstract

Current standards for assessment of tumour response to therapy (a) categorise therapeutic efficacy values, inappropriate for patient-specific and deterministic studies, (b) neglect the natural growth characteristics of tumours, (c) are based on tumour shrinkage, inappropriate for cytostatic therapies, and (d) do not accommodate integration of functional/biological means of therapeutic efficacy assessed with, for example, positron emission tomography or magnetic resonance imaging, with data from anatomical changes in tumour.

Page Manager: Webmaster|Last update: 9/11/2012
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