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Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation

Journal article
Authors Vikte Lionikaite
Petra Henning
Christina Drevinge
Furqan A. Shah
Anders Palmquist
P. Wikström
Sara H Windahl
Ulf H Lerner
Published in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume 33
Issue 4
Pages 5237-5247
ISSN 1530-6860
Publication year 2019
Published at Institute of Clinical Sciences, Department of Biomaterials
Centre for Bone and Arthritis Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 5237-5247
Language en
Keywords osteoblasts retinoids, physical activity, Raman spectroscopy
Subject categories Internal medicine


Increased vitamin A consumption is associated with decreased cortical bone mass and increased fracture risk in humans. Rodent studies have demonstrated that hypervitaminosis A increases cortical bone resorption, whereas the importance of the effects on bone formation is less well defined. We used an experimental model of increased bone formation by loading of the tibiae to investigate the effect of vitamin A on bone formation. Control [retinol activity equivalents (RAE) 4.5 µg/g chow] or vitamin A (RAE 60 µg/g chow) diets were given to female C57BL/6N mice for 4 wk, after which the tibiae were subjected to axial loading on alternate days for 2 wk, while the diets were continued. Vitamin A inhibited the loading-induced increase in trabecular and cortical bone volume. This was attributed to inhibition of loading-induced increase in osteoblast number and activity, and expression of osteoblastic genes Sp7, Alpl, and Col1a1 in cortical bone. Vitamin A, loading, and combination thereof also resulted in site-specific effects on bone composition measured by Raman spectroscopy. In summary, a clinically relevant dose of vitamin A suppresses the loading-induced gain of bone mass by decreasing bone formation. These observations may have implications for regulation of bone mass caused by physical activity and the risk of osteoporosis in humans.-Lionikaite, V., Henning, P., Drevinge, C., Shah, F. A., Palmquist, A., Wikström, P., Windahl, S. H., Lerner, U. H. Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation.

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