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Immediate injection pain in infants aged 18 months during vaccination against measles, mumps and rubella with either Priorix or MMR-II

Journal article
Authors N. Knutsson
U. B. Jansson
Bernt Alm
Published in Vaccine
Volume 24
Issue 31-32
Pages 5800-5
ISSN 0264-410X (Print)
Publication year 2006
Published at Institute of Clinical Sciences
Pages 5800-5
Language en
Keywords Child, Preschool, Double-Blind Method, Female, Humans, Infant, Injections, Intramuscular, Male, Measles/*epidemiology/prevention & control, Measles-Mumps-Rubella Vaccine/*adverse effects, Mumps/*epidemiology/prevention & control, Pain/chemically induced/epidemiology, *Pain Measurement/methods, Rubella/*epidemiology/prevention & control, Vaccination/adverse effects
Subject categories Medical and Health Sciences


The aim of this study was to investigate whether, the vaccine Priorix causes less immediate injection pain than MMR-II in vaccination of infants aged 18-24 months who were offered vaccine against measles, mumps and rubella. The infants were randomised into one of the two vaccine groups (Priorix/MMR-II in a double-blind study. One observer assessed pain, using CHEOPS (Children's Hospital Eastern Ontario Pain scale), and the parent used the Visual Analogue Pain scale (VAS). Pain assessment was made in 295 infants. Mean age was 19.08 months. Mean VAS value was 2.3/5.2 for Priorix and MMR-II, respectively (p<0.001). Mean CHEOPS value was 1.9/6.1 for Priorix and MMR-II, respectively (p<0.001). The study shows that Priorix gives less immediate injection pain than MMR-II.

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