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Influence of indomethacin on the regeneration of cortical bone within titanium implants in rabbits.

Journal article
Authors Lars Sennerby
Peter Kälebo
Peter Thomsen
Tomas Albrektsson
Published in Biomaterials
Volume 14
Issue 2
Pages 156-8
ISSN 0142-9612
Publication year 1993
Published at Institute of Odontology
Institute of Surgical Sciences, Department of Biomaterials
Institute of Selected Clinical Sciences, Department of Radiology
Pages 156-8
Language en
Keywords Analysis of Variance, Animals, Densitometry, Female, Indomethacin, pharmacology, Male, Microradiography, Osseointegration, drug effects, Prostheses and Implants, Rabbits, Tibia, Titanium
Subject categories Basic Medicine


The influence of indomethacin on cortical bone regeneration was studied in bone harvest chambers made of commercially pure titanium and inserted in rabbit tibia. Newly formed bone was harvested in situ every 3 wk for 33 wk. Indomethacin (1 mg/kg body weight) was given daily as subcutaneous injections for two periods, followed by two control periods with no drug administration and the same schedule was followed for indomethacin at a dose of 4 mg/kg body weight. These indomethacin dosages did not statistically influence the cortical bone regeneration.

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