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Agreement between patient reported outcomes and clinical reports after radical prostatectomy - a prospective longitudinal study

Journal article
Authors David Bock
Eva Angenete
A. Bjartell
Jonas Hugosson
Gunnar Steineck
Sofie Walming
P. Wiklund
Eva Haglind
Published in Bmc Urology
Volume 19
Pages 10
ISSN 1471-2490
Publication year 2019
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Clinical Sciences, Department of Oncology
Institute of Clinical Sciences, Department of Urology
Pages 10
Language en
Keywords Agreement, Questionnaire, Prostate cancer, Prostatectomy, Case-report, form, quality-of-life, medical-records, self-report, questionnaire data, low, kappa, cancer, care, comorbidity, concordance, morbidity
Subject categories Cancer and Oncology, Urology and andrology


BackgroundIn clinical research information can be retrieved through various sources. The aim is to evaluate the agreement between answers in patient questionnaires and clinical reports in a study of patients after radical prostatectomy and patient characteristics associated with agreement between these two data sources.MethodsIn the prospective non-randomized longitudinal trial LAParoscopic Prostatectomy Robot Open (LAPPRO) 4003 patients undergoing radical prostatectomy at 14 centers in Sweden were followed. Analysis of agreement is made using a variety of methods, including the recently proposed Gwet's AC1, which enables us to handle the limitations of Cohen's Kappa where agreement depends on the underlying prevalence.ResultsThe incidence of postoperative events was consistently reported higher by the patient compared with the clinical reports for all outcomes. Agreement regarding the absence of events (negative agreement) was consistently higher than agreement regarding events (positive agreement) for all outcome variables. Overall impression of agreement depends on which measure used for the assessment. The previously reported desirable properties of Gwet's AC1 as well as the patient characteristics associated with agreement were confirmed.ConclusionThe differences in incidence and agreement across the different variables and time points highlight the importance of carefully assessing which source of information to use in clinical research.

Page Manager: Webmaster|Last update: 9/11/2012

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