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Anticancer Drug Tamoxifen Affects Catecholamine Transmitter Release and Storage from Single Cells.

Journal article
Authors Zahra Taleat
Anna Larsson
Andrew G Ewing
Published in ACS chemical neuroscience
Volume 10
Issue 4
Pages 2060-9
ISSN 1948-7193
Publication year 2019
Published at Department of Chemistry and Molecular Biology
National Center for Imaging Mass Spectrometry
Pages 2060-9
Language en
Links dx.doi.org/10.1021/acschemneuro.8b0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Analytical Chemistry

Abstract

Electrochemical measurements of exocytosis combined with intracellular vesicle impact electrochemical cytometry have been used to evaluate the effect of an anticancer drug, tamoxifen, on catecholamine release at the single-cell level. Tamoxifen has been used for over 40 years to treat estrogen receptor-positive breast cancers during both early stages of the disease and in the adjuvant setting. Tamoxifen causes memory and cognitive dysfunction, but the reasons for the cognitive impairment and memory problems induced by this anticancer drug are not well-known. We show that tamoxifen, through a nongenomic mechanism, can modulate both exocytosis and vesicle catecholamine storage in a model cell line. The results indicate that exocytosis is inhibited at high concentrations of tamoxifen and is stimulated at low levels. Tamoxifen also elicits a significant concentration-dependent change in total catecholamine content of single vesicles, while sub-nanomolar concentrations of the drug have stimulatory activity on the catecholamine content of vesicles. In addition, it has profound effects on storage at higher concentrations. Tamoxifen also reduces the intracellular free Ca2+ but only at micromolar concentration, by acting on voltage-gated Ca2+ channels, which likely affects neurotransmitter secretion.

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