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Nontuberculous Mycobacterial Diseases in Humans

Chapter in book
Authors Lars-Olof Larsson
Rutger Bennet
Margareta Eriksson
Bodil Jönsson
Malin Ridell
Published in Nontuberculous Mycobacteria (NTM) - Microbiolocical, Clinical and Geografical distribution) / Editors: Ali Akbar and Parissa Farnia
Pages 101-119
ISBN 978-0-12-814692-7
Publisher Academic Press
Publication year 2019
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Biomedicine, Department of Infectious Medicine
Pages 101-119
Language en
Links https://doi.org/10.1016/B978-0-12-8...
Keywords Mycobacteriosis; clinical presentation; diagnosis; treatment
Subject categories Clinical Laboratory Medicine, Infectious Medicine

Abstract

The number of patients infected with nontuberculous mycobacteria (NTM) is increasing and presents severe health problems. NTM infections in children are not uncommon and differ in several aspects from NTM infections in adults. In children, lymph nodes are most often infected, while lung infections dominate among adults. Thus, this chapter on NTM infections will focus on infections in children and pulmonary infections in adults. The reason why NTM diseases have been more commonly recognized is partly due to increased awareness and improved diagnostic methods. In addition, the number of patients with impaired resistance to infections has increased and such conditions are important risk factors for developing NTM disease. However, many NTM patients, particularly children, have no known predisposing condition. In addition, spontaneous resolution is common among children. Diagnosis and treatment are challenging since many patients suffer from other diseases and many NTM are resistant to commonly used drugs. Therapy is, therefore, generally complex and prolonged and side effects are common.

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