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Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of (161)Tb-folate and (177)Lu-folate.

Journal article
Authors Stephanie Haller
Giovanni Pellegrini
Christiaan Vermeulen
Nicholas P van der Meulen
Ulli Köster
Peter Bernhardt
Roger Schibli
Cristina Müller
Published in EJNMMI research
Volume 6
Issue 1
Pages 13
ISSN 2191-219X
Publication year 2016
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 13
Language en
Links dx.doi.org/10.1186/s13550-016-0171-...
Keywords Radionuclide therapy, Tb-161, Lu-177, Auger/conversion electrons, Radionephropathy, Kidney, TUMOR-THERAPY, NORMAL-TISSUES, IN-VITRO, FOLATE, CANCER, LU-177, TB-161, MECHANISMS, CONJUGATE, DOSIMETRY
Subject categories Radiological physics

Abstract

The radiolanthanide (161)Tb has, in recent years, attracted increasing interest due to its favorable characteristics for medical application. (161)Tb exhibits similar properties to the widely-used therapeutic radionuclide (177)Lu. In contrast to (177)Lu, (161)Tb yields a significant number of short-ranging Auger/conversion electrons (≤50 keV) during its decay process. (161)Tb has been shown to be more effective for tumor therapy than (177)Lu if applied using the same activity. The purpose of this study was to investigate long-term damage to the kidneys after application of (161)Tb-folate and compare it to the renal effects caused by (177)Lu-folate.

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