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TLR5, a novel mediator of innate immunity-induced osteoclastogenesis and bone loss

Journal article
Authors A. Kassem
Petra Henning
Bert Kindlund
Catharina Lindholm
Ulf H Lerner
Published in Faseb Journal
Volume 29
Issue 11
Pages 4449-4460
ISSN 0892-6638
Publication year 2015
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Centre for Bone and Arthritis Research
Pages 4449-4460
Language en
Links dx.doi.org/10.1096/fj.15-272559
Keywords inflammation, Toll-like receptors, osteoclasts, bone resorption, flagellin, toll-like-receptors, nf-kappa-b, rheumatoid-arthritis, signaling, pathways, in-vivo, resorption, cells, rankl, differentiation, lipopolysaccharide, Biochemistry & Molecular Biology, Life Sciences & Biomedicine - Other, Topics, Cell Biology
Subject categories Immunology in the medical area, Endocrinology

Abstract

Accumulating evidence points to the importance of the innate immune system in inflammation-induced bone loss in infectious and autoimmune diseases. TLRs are well known for being activated by ligands expressed by bacteria, viruses, and fungi. Recent findings indicate that also endogenous ligands in inflammatory processes are important, one being a TLR5 agonist present in synovial fluid from patients with rheumatoid arthritis (RA). We found that activation of TLR5 by its specific ligand, flagellin, caused robust osteoclast formation and bone loss in cultured mouse neonatal parietal bones dependent on increased receptor activator of NF-kappa B ligand (RANKL): osteoprotegerin ratio, with half-maximal stimulation at 0.01 mu g/ml. Flagellin enhanced Rankl mRNA in isolated osteoblasts by a myeloid differentiation primary response gene 88 and NF-kappa B-dependent mechanism. Injection of flagellin locally over skull bones in 5-wk-oldmice resulted in increased mRNA expression of Rankl and osteoclastic genes, robust osteoclast formation, and bone loss. The effects in vitro and in vivo were absent in Tlr5(-/-) mice. These data show that TLR5 is a novel activator of RANKL and osteoclast formation and, therefore, a potential key factor in inflammation-induced bone erosions in diseases like RA, reactive arthritis, and periodontitis. TLR5 might be a promising novel treatment target for prevention of inflammatory bone loss.

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