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Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?

Journal article
Authors Richard J Sylvester
Willem Oosterlinck
Sten Holmäng
Matthew R Sydes
Alison Birtle
Sigurdur Gudjonsson
Cosimo De Nunzio
Kikuo Okamura
Eero Kaasinen
Eduardo Solsona
Bedeir Ali-El-Dein
Can Ali Tatar
Brant A Inman
James N'Dow
Jorg R Oddens
Marek Babjuk
Published in European urology
Volume 69
Issue 2
Pages 231–244
ISSN 1873-7560
Publication year 2016
Published at Institute of Clinical Sciences, Department of Urology
Pages 231–244
Language en
Links dx.doi.org/10.1016/j.eururo.2015.05...
Keywords Chemotherapy; Meta-analysis; Non–muscle-invasive bladder cancer; Single instillation; Systematic review
Subject categories Urology and andrology

Abstract

The European Association of Urology non-muscle-invasive bladder cancer (NMIBC) guidelines recommend that all low- and intermediate-risk patients receive a single immediate instillation of chemotherapy after transurethral resection of the bladder (TURB), but its use remains controversial.

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