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| Authors |
Stefania Mondello Radu Constantinescu Henrik Zetterberg Ulf Andreasson Björn Holmberg Andreas Jeromin |
|---|---|
| Published in | Parkinsonism & related disorders |
| Volume | 20 |
| Issue | 4 |
| Pages | 382–387 |
| ISSN | 1873-5126 |
| Publication year | 2014 |
| Published at |
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry |
| Pages | 382–387 |
| Language | en |
| Links |
dx.doi.org/10.1016/j.parkreldis.201... |
| Keywords | α-Synuclein; UCH-L1; Cerebrospinal fluid; Parkinson's disease; Atypical parkinsonian disorders |
| Subject categories | Neurochemistry |
There is an unmet need for biomarkers for Parkinson's disease (PD) and atypical parkinsonian disorders (APD). α-Synuclein, linked to the pathogenesis of PD, is a promising biomarker candidate in need of further investigation. The ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a pivotal component of the ubiquitin proteasome system which seems to be disturbed in PD, may also be involved in the pathogenesis of this disorder.
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