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The alpha1,3GalT knockout/alpha1,2FucT transgenic pig does not appear to have an advantage over the alpha1,3GalT knockout pig with respect to glycolipid reactivity with human serum antibodies.

Journal article
Authors Mette Diswall
John Benktander
Jonas Ångström
Susann Teneberg
Michael Breimer
Published in Xenotransplantation
Volume 21
Issue 1
Pages 57-71
ISSN 1399-3089
Publication year 2014
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 57-71
Language en
Links dx.doi.org/10.1111/xen.12071
Keywords blood group ABO antigens;genetic modification;glycosphingolipids;pig;small intestine;xenotransplantation;α1,2fucosyltransferase transgenic;α1,3galactosyltransferase knockout
Subject categories Transplantation surgery

Abstract

The human H-transferase (α2FucT) was introduced in Gal-negative pigs to produce pig organs not only free from Gal-antigens, but also in which the uncapped N-acetyllactosamine precursor had been transformed into non-xenogenic blood group H type 2 compounds. This work is the first descriptive analysis of glycolipids from the GalT-KO/FucT-TG pig. The aim was to investigate the cell membrane antigens in GalT-KO/FucT-TG tissues to explore its efficacy as an organ donor. Also, detailed knowledge on the correlation between the cellular glycosyltransferase configuration and the resulting carbohydrate phenotype expression is valuable from a basic glycobiological perspective.

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