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Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity.

Journal article
Authors Olle Bergman
Lars Westberg
Paul Lichtenstein
Elias Eriksson
Henrik Larsson
Published in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
Pages 1-10
ISSN 1469-5111
Publication year 2011
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 1-10
Language en
Links dx.doi.org/10.1017/S146114571100050...
Keywords brain-derived neurotrophicfactorpolymorphism, attention deficit, hyperactivity
Subject categories Pharmacology and Toxicology

Abstract

Several studies have, with conflicting results, investigated the relationship between the Val66Met polymorphism in brain-derived neurotrophic factor (BDNF) and attention deficit hyperactivity disorder (ADHD). We assessed longitudinal, quantitative phenotypes of hyperactivity-impulsivity and inattention in order to determine whether the Val66Met polymorphism is associated with age-specific and/or persistent symptoms of hyperactivity-impulsivity and/or inattention in a community-based cohort of 1236 Swedish individuals for which ADHD symptom data were collected when the participants were aged 8-9, 13-14 and 16-17 yr. The Met allele was associated with symptoms of ADHD at ages 8-9 and 13-14 yr. A multivariate regression analysis revealed that the observed effect of the Met allele on ADHD symptoms reflects an influence on persistent hyperactivity-impulsivity symptoms. The present findings support the hypothesis that BDNF is involved in the pathogenesis of ADHD. The results highlight the importance of distinguishing between hyperactivity-impulsivity and inattention, respectively, and demonstrate the value of using a longitudinal approach in genetic studies of ADHD symptoms.

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