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Cystatin C in cerebrospinal fluid and multiple sclerosis

Journal article
Authors Sara Folkesson Hansson
A. H. Simonsen
Henrik Zetterberg
O. Andersen
Sara Haghighi
I. Fagerberg
U. Andreasson
Ann Brinkmalm-Westman
Anders Wallin
Ulla Rüetschi
Kaj Blennow
Published in Ann Neurol
Volume 62
Issue 2
Pages 193-196
Publication year 2007
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 193-196
Language en
Subject categories Neurochemistry


OBJECTIVE: A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS). METHODS: Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects. RESULTS: Full-length CysC (13.4kDa) concentration was similar in MS and control samples. The 12.5kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C. INTERPRETATION: The 12.5kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS. Ann Neurol 2007;62:193-196.

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