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Longstanding psychological stress in relation to biomarkers of neuronal dysfunction in cerebrospinal fluid: a 25-year follow-up study in women

Journal article
Authors Lena Johansson
Simona Sacuiu
Silke Kern
Xinxin Guo
Henrik Zetterberg
Kaj Blennow
Anna Zettergren
Ingmar Skoog
Published in Neurobiology of Aging
Volume 80
Pages 111-115
ISSN 0197-4580
Publication year 2019
Published at Institute of Neuroscience and Physiology
Centre for Ageing and Health (Agecap)
Pages 111-115
Language en
Keywords Stress, Neuropathology, Neurodegeneration, Cerebrospinal fluid, Aging, alzheimers-disease, cognitive decline, brain atrophy, population, protein, risk, personality, distress, dementia, markers, Geriatrics & Gerontology, Neurosciences & Neurology, leans, la, v886, p172
Subject categories Neurosciences


Longstanding psychological stress has been associated with increased risk of neurodegenerative disorders, such as dementia and Alzheimer's disease. In a prospective population study of women (n = 81), we tested if midlife stress (mean age 49 years) was associated with late-life biomarkers of neuro-degeneration in cerebrospinal fluid (CSF) (mean age 74 years) in linear regression models. It was found that women who report of stress at baseline (n = 20) had higher levels of CSF visinin-like protein-1 (VILIP-1) (age adjusted beta = 0.113, p = 0.017) and CSF myelin basic protein (beta = 0.060, p = 0.030) compared with women without midlife stress (n = 61). There was also a trend observed for higher CSF neurofilament light (beta = 0.133, p = 0.056). In addition, longer periods of stress (i.e., stress at 2-3 midlife examinations) were associated with higher levels of CSF VILIP-1. The results suggest that longstanding stress might be associated with neurodegenerative processes in the brain, as CSF VILIP-1 is an unspecific marker for neuronal injury and CSF myelin basic protein reflects neuroaxonal demyelination. (C) 2019 Elsevier Inc. All rights reserved.

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Utskriftsdatum: 2020-05-28