To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

C-Peptide Suppression Dur… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Contact form


Note! If you want an answer on a question you must specify your email address

C-Peptide Suppression During Insulin Infusion in the Extremely Preterm Infant Is Associated With Insulin Sensitivity

Journal article
Authors William Hellström
Ingrid Hansen-Pupp
Gunnel Hellgren
Eva Engström
Lennart Stigson
Karin Sävman
David Ley
Chatarina Löfqvist
Published in Journal of Clinical Endocrinology and Metabolism
Volume 104
Issue 9
Pages 3902-3910
ISSN 0021-972X
Publication year 2019
Published at Institute of Neuroscience and Physiology
Institute of Biomedicine
Institute of Health and Care Sciences
Institute of Clinical Sciences, Department of Pediatrics
Pages 3902-3910
Language en
Subject categories Clinical Medicine


Context Little is known about the individual response of glucose-regulating factors to administration of exogenous insulin infusion in extremely preterm infants. Objective To evaluate longitudinal serum concentrations of insulin, C-peptide, and plasma glucose levels in a high-frequency sampling regimen in extremely preterm infants treated with insulin because of hyperglycemia. Design Prospective longitudinal cohort study. Setting Two university hospitals in Sweden between December 2015 and September 2016. Patients and Intervention Serum samples were obtained from nine extremely preterm infants, gestational age between 22 (+3) and 26 (+5) weeks (+ days), with hyperglycemia (plasma-glucose >10 mmol/L) at the start of insulin infusion, at 12, 24, and every 24 hours thereafter during ongoing infusion, and 12, 24, and 72 hours after the end of insulin infusion. Main outcome measures Longitudinal serum concentrations of insulin and C-peptide and plasma glucose levels. Results During insulin infusion, the serum C-peptide concentrations decreased compared with at start of infusion (P = 0.036), and then increased after ending the infusion. Individual insulin sensitivity based on the nonfasting plasma glucose/insulin ratio at the start of insulin infusion correlated with the initial decrease in serum ΔC-peptide[after 12h] (P = 0.007) and the degree of lasting decrease in serum ΔC-peptide[after end of infusion] (P = 0.015). Conclusion Exogenous insulin infusion suppressed the C-peptide concentration to individually different degrees. In addition, the effect of insulin infusion on β cells may be linked to individual insulin sensitivity, where a low insulin sensitivity resulted in a more pronounced decrease in C-peptide during insulin infusion.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?