To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A controlled study of col… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Contact form


Note! If you want an answer on a question you must specify your email address

A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome.

Journal article
Authors Lena Öhman
Stefan Isaksson
Anna Lundgren
Magnus Simrén
Henrik Sjövall
Published in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Volume 3
Issue 10
Pages 980-6
ISSN 1542-3565
Publication year 2005
Published at Institute of Medical Microbiology/Immunology
Institute of Internal Medicine, Dept of Medicine
Pages 980-6
Language en
Keywords Adult, CD8-Positive T-Lymphocytes, immunology, Colitis, Ulcerative, immunology, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunohistochemistry, Integrin beta Chains, analysis, Interferon Type II, analysis, Intestinal Mucosa, immunology, Irritable Bowel Syndrome, immunology, Male, T-Lymphocytes, immunology
Subject categories Gastroenterology and Hepatology


BACKGROUND & AIMS: The mechanisms behind irritable bowel syndrome (IBS) are incompletely understood. Recently several studies have suggested a low-grade colonic inflammation as initiator of the gut dysfunctions recorded in this patient group. The aim of this study was to characterize the phenotype and homing properties of colonic and peripheral blood lymphocytes in patients with IBS. METHODS: Patients with IBS (n=33), defined by the Rome II criteria, were compared with UC patients (n=23) and control subjects (n=15) without gastrointestinal symptoms. Colonic and peripheral blood lymphocytes were analyzed by flow cytometry. Secretion of IFN-gamma from intestinal biopsies was determined by enzyme-linked immunosorbent assay, and immunohistochemical staining of colonic biopsies was performed. RESULTS: IBS patients displayed an increased frequency of peripheral blood CD4+ and CD8+ T cells expressing the gut homing integrin beta7. Accordingly, IBS and UC patients had an augmented frequency of lamina propria CD8+ T cells in the ascending colon as compared with control subjects. The frequency of intestinal T cells expressing integrin beta7+ was unaltered in IBS and UC patients, although the expression of mucosal addressin cell adhesion molecule-1+ endothelium, the ligand for integrin beta7, was increased in the ascending colon of IBS and UC patients as compared with control subjects. CONCLUSIONS: Patients with IBS exhibit an enhanced immune activity in the gut and an increased frequency of integrin beta7+ T lymphocytes in the peripheral blood. Our data further support the hypothesis of IBS being at least partially an inflammatory disorder.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?

Denna text är utskriven från följande webbsida:
Utskriftsdatum: 2020-07-13