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Mass spectrometric profiling of lipids in intestinal tissue from rats fed cereals processed for medical conditions

Journal article
Authors Masoumeh Dowlatshahi Pour
Eva Jennische
Stefan Lange
Andrew G Ewing
Per Malmberg
Published in Biointerphases
Volume 11
Issue 2
Pages 1-7
ISSN 1934-8630
Publication year 2016
Published at Institute of Biomedicine
Department of Chemistry and Molecular Biology
Pages 1-7
Language en
Subject categories Chemical Sciences


Time-of-flight secondary ion mass spectrometry (ToF-SIMS) was used for lipid profiling of intestine tissue sections from rats fed specially processed cereals and rats fed ordinary feed as a control. This cereal is known to increase the activity of antisecretory factor in plasma and the exact mechanism for the activation process at the cellular level is unclear. ToF-SIMS has been used to track food induced changes in lipid content in intestinal tissue sections to gain insight into the possible mechanisms involved. Data from 20 intestine sections belonging to four different rats from each group of control and specially processed cereals-fed rats were obtained using the stage scan macroraster with a lateral resolution of 5 lm. Data were subsequently subjected to orthogonal partial least squares discriminant analysis. The data clearly show that changes of certain lipids are induced by the specially processed cereal feed. Scores plots show a well-defined separation between the two groups. The corresponding loading plots reveal that the groups separate mainly due to changes of vitamin E, phosphocholine, and phosphosphingolipid fragments, and that for the c18:2 fatty acid. The observed changes in lipids might give insight into the working mechanisms of antisecretory factor in the body, and this has been successfully used to understand the working mechanism of specially processed cereal-induced antisecretory factor activation in intestine.

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