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Food-induced antisecretory factor activity is correlated with small bowel length in patients with intestinal resections.

Journal article
Authors Stefan Lange
Ingvar Bosaeus
Eva Jennische
Ewa Johansson
Birgitta K Lundgren
Ivar Lönnroth
Published in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Volume 111
Issue 10
Pages 985-8
ISSN 0903-4641
Publication year 2003
Published at Institute of Anatomy and Cell Biology
Institute of Internal Medicine, Dept of Clinical Nutrition
Institute of Laboratory Medicine, Dept of Clinical Bacteriology
Pages 985-8
Language en
Keywords Adult, Case-Control Studies, Cereals, Crohn Disease, diet therapy, pathology, surgery, Diarrhea, prevention & control, Dietary Supplements, Female, Food Handling, Humans, Intestine, Small, pathology, physiopathology, surgery, Male, Middle Aged, Neuropeptides, biosynthesis
Subject categories Clinical bacteriology, Microbiology in the medical area


Specially processed cereals (SPC) can increase antisecretory factor (AF) activity in humans with an intact intestine. The aim of the present study was to investigate whether AF synthesis could be induced in patients who had been subjected to intestinal resections. Eight patients with varying extents of intestinal resections due to Crohn's disease and six healthy controls participated. All subjects received 54 g SPC daily for 2 weeks. Plasma AF activity was determined before, during and after the treatment period. Baseline diet and medications were kept unchanged. The patients registered the daily number of bowel movements. The SPC diet increased AF activity in all controls. In the patients there was a significant correlation between the length of the remaining small intestine and AF induction (r=0.94, p<0.01) and only those patients with a remaining small intestine of about 3 m reached AF values comparable to those in healthy subjects. It is concluded that small bowel length is related to the ability of humans to induce AF activity by dietary means.

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