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Regulation of carboxylesterase 1 (CES1) in human adipose tissue.

Journal article
Authors Margareta Jernås
Bob Olsson
Peter Arner
Peter Jacobson
Lars Sjöström
Andrew Walley
Philippe Froguel
Philip G McTernan
Johan Hoffstedt
Lena M S Carlsson
Published in Biochemical and biophysical research communications
Volume 383
Issue 1
Pages 63-7
ISSN 1090-2104
Publication year 2009
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 63-7
Language en
Links dx.doi.org/10.1016/j.bbrc.2009.03.1...
Keywords Adipocytes, cytology, enzymology, Adipose Tissue, cytology, enzymology, Adult, Carboxylic Ester Hydrolases, biosynthesis, Female, Humans, Lipolysis, Male, Middle Aged, Obesity, enzymology, Weight Loss, Young Adult
Subject categories Molecular medicine (genetics and pathology)

Abstract

Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n=78 pairs, P=8.7x10(-18)) and brothers (n=12 pairs, P=0.048). CES1 expression was higher in subcutaneous compared with omental adipose tissue in lean (P=0.027) and obese subjects (P=0.00036), and reduced during diet-induced weight loss (n=24, weeks 8, 16, and 18 compared to baseline, P<0.0001 for all time points). CES1 expression was higher in isolated adipocytes compared with intact adipose tissue (P=0.0018) and higher in large compared with small adipocytes (P=4.1x10(-6)). Basal and stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity.

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