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OPEN POSITIONS Postdoc in computational biochemistry with the focus on the development of new molecular modelling tools

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

The research group in theoretical biochemistry/computer-based modeling is led by Prof. Leif Eriksson, and consists of researcher Dr. Anna Reymer, two postdoctoral fellows, three doctoral students, and several master and bachelor students. We work in a number of areas, from studies of membrane systems to protein structure, function and interaction, DNA transcription, biological regulation, DNA damage, drug development, especially in antibiotics and cancer, and development of new molecular modeling tools. The group is very international, and has a large network of collaborations both within Sweden and abroad. We participate in various international research collaborative networks, for example MSCA-RISE. We have access to all relevant software and have a generous allocation of computer time at national supercomputer centers.

The aim of the project is to develop new molecular modeling tools, compatible with existing molecular dynamics programs (e.g. emplemented via MD library PLUMED), to enable modeling of controlled mechanical deformation of DNA molecules. The tools will enable stretching, bending, and twisting – three major DNA mechanical deformations observed in biological processes, such as DNA transcription. The tools will enable mechanical manipulation of DNA fragments of any length and curvature, alone or in complexes with other molecules, and are planned to be compatible with atomistic and coarse-grained molecular dynamics programs. With the help of the new tools we will be able to 1) gain an insight into the catalytic role of deformed non-equilibrium structures of DNA for macromolecular complexation, relevant to biological function, and 2) increase computational efficiency by following biological reactions with steered molecular dynamics simulation.

Job assignments

The postdoc will primarily work with the development of molecular modeling tools, compatible with the existing molecular dynamics programs (implemented through the MD library PLUMED), to enable controlled mechanical deformation of DNA molecules. Work assignments also include conducting MD simulations to test the developed tools, as well as preparation of scientific articles, participation in conferences and mentorship of younger researchers.

Eligibility

To qualify as a postdoctoral fellow, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree.Preference will be given to candidates who have been awarded the degree no more than three years before the application deadline and who have not held a post-doc position within the same or similar subject area at the University of Gothenburg for more than one year.

Assessment

We are looking for a candidate who has shown scientific skills in the field of computational chemistry, computational physics or bioinformatics. You are expected to have experience from a number of areas such as programming for scientific applications, preferably in C++; experience with performing computer simulations, and experience with HPC. Scientific competence is mainly based on peer-reviewed publications in scientific journals and invited lectures at international conferences. Experience with programming in C ++, and molecular dynamic simulations of biomolecules, as well as knowledge in linear algebra will be considered an advantage.

Employment

The position is a fixed-term employment for two years, fulltime (100%), located at the Department of Chemistry and Molecular Biology in Gothenburg. First day of employment will be in January.

Contacts

Regarding the position please contact Anna Reymer, project leader
anna.reymer@gu.se

Markus Tamas, Head of Department
markus.tamas@cmb.gu.se

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

The application should include:

  •  CV including complete list of publications;
  • personal letter;
  • PhD certificate;
  • two publications, most relevant for the position;
  • two references that we can contact.

Closing date: 2019-12-10 

The University of Gothenburg tackles society’s challenges with diverse knowledge. 47 500 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

Page Manager: rekrytering@gu.se|Last update: 2/23/2017
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