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OPEN POSITIONS PhD student position in medical science - CRISPR Screens for Pro-Oxidant Cancer Therapies

Project title: Genome-wide Lentiviral CRISPR Screens for Pro‐Oxidant Cancer Therapies

Job assignments

Supplementation with antioxidants was long considered to protect against cancer, but the paradigm has changed and accumulating evidence suggest that cancer cells struggle with oxidative stress and that reactive oxygen species may be an ally in the fight against cancer. The oxidative stress weakness of cancer cells is likely a direct consequence of their lifestyle – to maintain perpetual proliferation at the expense of other needs. Pro-oxidant therapies may therefore be more toxic to cancer cells than normal cells. The goal of this PhD-project is to develop therapeutic strategies that exploit the oxidative stress weakness of cancer cells.

We have set up a CRISPR/Cas9 platform in human cancer cell lines for genome-wide screens of genetic modifiers of pro-oxidant drugs (gene knockouts that worsen or rescue cells from drug effects). Data from such screens can reveal mechanisms of drug effects, potential drug resistance mechanisms, and new targets for combination therapies that enhance the effect of the drug. The findings will be validated in human cancer cell lines and mouse xenograft models. The CRISPR technique confers unprecedented power for this type of analyses and the approach is mechanistic by default – we define causal interactions between genes and drugs. The project offers a great opportunity to address conceptually challenging questions in tumor biology and to learn advanced and modern genome editing techniques.

Eligibility

To be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have:
1. completed a degree at a second-cycle level, or
2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or
3. acquired equivalent knowledge in some other way in Sweden or abroad.

The specific entry requirement is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Employment

Time limited employment (temporary), 4 years. Extent: 100%. Location: Sahlgrenska Academy, Institute of Medicine. First day of employment: as agreed.

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

Salaries for doctoral students are regulated in a local agreement at the University.

For further information regarding the position

For more information about the project please contact the project supervisor Per Lindahl, +46(0)31-3423832, per.lindahl@wlab.gu.se

For more information regarding PhD education at Sahlgrenska Academy visit http://sahlgrenska.gu.se/english/doctoral-student-portal/

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date 2018-01-31

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

Page Manager: rekrytering@gu.se|Last update: 2/23/2017
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