The course Experimental Systems Biology provides a theoretical and practical introduction of advanced working methods in systems biology by using the Synthetic Genetic Array (SGA) analysis as an example. As a student, you will have access to the research infrastructure Large-scale cell-based screening and use the robotic systems to perform the required systems biology experiments for the course.
During the course, you will learn how to design and modify a working protocol, perform a complete SGA experiment and confirm the screening results. You will also learn to create mathematical models of cellular modules for specific metabolic systems. The course also provides in-depth knowledge of how to analyse, summarize and present the screening results to fullfil the requirements for a scientific publication.
After completing the course, you should be able to:
- design and modify systems biology tools for genome-wide genetic analysis
- have an understanding of how the Synthetic Genetic Array (SGA) approach works in theory and practice
- conduct SGA experiments and other similar yeast genome-wide screens
- verify and summarize data acquired from the SGA experiments
- collect, analyse and interpret genome-wide screening data.
Teaching methods include lectures, seminars, project works as well as laboratory work. In addition, there are lectures and group activities that provide a deeper understanding of scientific writing. All scheduled events except lectures are mandatory.