Large-scale analysis of biological data, such as DNA and protein sequences, have recently become a natural part of biological research. Bioinformatics is about analysing biological data using computers and computer programs.
The course in Advanced Bioinformatics gives you a better understanding of the bioinformatic methods and algorithms used in different types of analyses and of the way data and results are presented. The course will provide the necessary skills needed to perform large-scale analyses, for example assembly and annotation of genomes, analysis of gene expression and constructing phylogenetic trees. You will also learn basic programming in Linux/Unix.
The course consists of four parts
1. Introduction. You will learn about
- biological sequences: DNA, RNA, protein
- genome, different types of genes
- evolution of sequences, homology
- phylogenetic analyses
- sequence databases
- using bioinformatic tools
- algorithms and models used by tools
- working in a command-line environment.
2. In the second part, you will learn
- how you can assemble a genome using shorter sequences
- which techniques are available today
- the advantages and disadvantages of the different techniques
- different sequencing formats.
3. Population genomics and quantitative genomics, both in theory and in practice.
4. In the last part, you will learn more about gene expression analysis, ethics and databases.
The course consists of lectures, group exercises and seminars. You will also perform projects, individually or in small groups, and practicals. You will present your results orally or in written form by means of lab reports. At the end of the course, you will execute a shorter individual assigned task using bioinformatics tools and sequence databases.