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Women and Inflammation

Research group
Active research
Project owner
Sahlgrenska academy, Institute of Medicine, Department of Internal medicine and Clinical Nutrition, Krefting Research Centre

Short description

Sex hormones have major effects on the immune system, which greatly influences the risk of developing certain diseases. For example there is a clear female bias in the development of both autoimmune diseases and asthma. The research group studies how the female sex hormone estrogen affect immune responses during inflammatory diseases caused by autoimmunity, allergy or infections. The projects focus, among others, on determining whether the protective effects of estrogen on rheumatoid arthritis, osteoarthritis and osteoporosis are mediated via lymphocytes or stromal cells in lymph nodes and bone marrow. Another focus area is to define immunological mechanisms involved in the stimulating effects of estrogen on immune responses during infection- and allergy-induced airway inflammation. The projects range from basic research (in vitro and in