I am a postdoctoral researcher interested in the cellular influence of aberrant and misfolded proteins and its role in disease and aging. Highly experienced in molecular and biochemical studies of protein quality control in single cell eukaryotes and mammalian cells, where I have focused on the link between protein management and intracellular trafficking pathways such as autophagy and endocytosis.

I finished my doctoral studies in the end of 2015, obtaining a PhD in biology at the Faculty of Science of University of Gothenburg, Sweden. I did my doctoral studies in the lab of Professor Thomas Nyström at the department of Chemistry and Molecular Biology, studying cellular aging and protein quality control in the unicellular yeast Saccharomyces cerevisiae.

In 2017 I started as a post-doc researcher in Professor David Rubinsztein's lab at Cambridge University, funded by fellowships from EMBO and the Swedish Research council (VR). In my postdoctoral research project I am studying the regulation of autophagy, and the involvement of this process in neurodegeneration and cancer, working with mammalian cell culture and combining conventional techniques in biochemistry and cell biology with modern high-throughput methods of CRISPR/Cas9 screening and next-generation sequencing.

Publications

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy
regulation.

Sandra Malmgren Hill, Lidia Wrobel, David C Rubinsztein
Cell death and differentiation - 2019-01-01
Restricted access: spatial sequestration of damaged proteins during stress and
aging

Sandra Malmgren Hill, Sarah Hanzén, Thomas Nyström
Embo Reports - 2017-01-01
Selective protein degradation ensures cellular
longevity

Sandra Malmgren Hill, Thomas Nyström
eLife - 2016-01-01
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar
Functions

Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund, T. Amen, Anna Jorhov, Rebecca Josefson, D. Kaganovich, Beidong Liu, Thomas Nyström
Cell Reports - 2016-01-01
Damage Segregation and Cellular Rejuvenation in Saccharomyces
cerevisiae

Sandra Malmgren Hill
- 2015-01-01
The dual role of a yeast metacaspase: What doesn't kill you makes you
stronger.

Sandra Malmgren Hill, Thomas Nyström
BioEssays : news and reviews in molecular, cellular and developmental biology - 2015-01-01
Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein
Aggregates

J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao, Xuefeng Zhu, Sandra Malmgren Hill, Marija Cvijovic, Julia Fernandez-Rodriguez, Julie Grantham, Claes M Gustafsson, Beidong Liu, Thomas Nyström
PLoS Genetics - 2014-01-01
Life-span extension by a metacaspase in the yeast Saccharomyces
cerevisiae

Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström
Science - 2014-01-01
Segregation of protein aggregates involves actin and the polarity
machinery.

Beidong Liu, Lisa C Larsson, Vanessa Franssens, Xinxin Hao, Sandra Malmgren Hill, Veronica Andersson, Daniel Höglund, Jia Song, Xiaoxue Yang, David Öling, Julie Grantham, Joris Winderickx, Thomas Nyström
Cell - 2011-01-01