Per-Ola Norrby

PROFESSOR, ADJUNGERAD

Department of Chemistry & Molecular

Biology

Mail

pon@chem.gu.se

Visiting address

Medicinaregatan 9 c

41390 Göteborg

Postal address

Box 462

40530 Göteborg

About Per-Ola Norrby

Organic chemist specialized on the study of reaction mechanisms, in particular within homogeneous catalysis. Our most commonly used tools are different types of kinetic studies, in particular in competitive mode. We also use molecular modeling, such as quantum chemical calculations based on density functional theory.

A special in-house method is reaction specific force fields, i.e. Q2MM, which can be used to determine all possible pathways for a given chemical reaction.

Publications

Synthetic and mechanistic studies in enantioselective allylic substitutions catalysed by palladium complexes of a modular class of axially chiral quinazoline-containing
ligands

A. M. Carroll, M. McCarthy, P. M. Lacey, C. P. Saunders, D. J. Connolly, A. Farrell, B. V. Rokade, R. Goddard, P. Fristrup, Per-Ola Norrby, P. J. Guiry
Tetrahedron - 2020-01-01
An Improved Class of Phosphite-Oxazoline Ligands for Pd-Catalyzed Allylic Substitution
Reactions

M. Biosca, J. Salto, M. Magre, Per-Ola Norrby, O. Pamies, M. Dieguez
Acs Catalysis - 2019-01-01
The Manganese-Catalyzed Cross-Coupling Reaction and the Influence of Trace
Metals

C. Santilli, S. S. Beigbaghlou, A. Ahlburg, G. Antonacci, P. Fristrup, Per-Ola Norrby, R. Madsen
European Journal of Organic Chemistry - 2017-01-01
Manganese-Catalyzed Cross-Coupling of Aryl Halides and Grignard Reagents by a Radical
Mechanism

G. Antonacci, A. Ahlburg, P. Fristrup, Per-Ola Norrby, R. Madsen
European Journal of Organic Chemistry - 2017-01-01
Anomeric Effects in
Sulfamides

Eric Hansen, Elaine Limé, Per-Ola Norrby, Olaf Wiest
Journal of Physical Chemistry A - 2016-01-01
Kinetic and Theoretical Investigation of Iron(III)-Catalyzed Silane
Chlorination

Risto Savela, Henrik Grénman, Heidi Sundelin, Per-Ola Norrby, Dmitry Yu. Murzin, Reko Leino
ChemCatChem - 2016-01-01
Prediction of Stereochemistry using
Q2MM

Eric Hansen, Anthony R. Rosales, Brandon Tutkowski, Per-Ola Norrby, Olaf Wiest
Accounts of Chemical Research - 2016-01-01
Asymmetric Catalyzed Allylic Substitution Using a Pd/P-S Catalyst Library with Exceptional High Substrate and Nucleophile Versatility: DFT and Pd-pi-allyl Key Intermediates
Studies

J. Margalef, M. Coll, Per-Ola Norrby, O. Pamies, M. Dieguez
Organometallics - 2016-01-01
Mechanistic Insights into the Iridium-Catalyzed Hydrogenations of alpha,beta-Unsaturated
Ketones

J. Engel, S. Mersmann, Per-Ola Norrby, C. Bolm
Chemcatchem - 2016-01-01
Glycerol Upgrading via Hydrogen Borrowing: Direct Ruthenium- Catalyzed Amination of the Glycerol Derivative
Solketal

Anna Said Stålsmeden, José Luis Belmonte Vázquez, Kim van Weerdenburg, Rebecca Rae, Per-Ola Norrby, Nina Kann
ACS Sustainable Chemistry & Eneering - 2016-01-01
Stereoselectivity in (Acyloxy)borane-Catalyzed Mukaiyama Aldol
Reactions

J. M. Lee, X. Zhang, Per-Ola Norrby, P. Helquist, O. Wiest
Journal of Organic Chemistry - 2016-01-01
Conformational Preferences of a Tropos Biphenyl Phosphinooxazoline-a Ligand with Wide Substrate
Scope

R. Bellini, M. Magre, M. Biosca, Per-Ola Norrby, O. Pamies, M. Dieguez, C. Moberg
Acs Catalysis - 2016-01-01
Single-Flask Multicomponent Palladium-Catalyzed α,γ-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon
Scaffolds

Michael Grigalunas, Per-Ola Norrby, Olaf Wiest, Paul Helquist
Angewandte Chemie - International Edition - 2015-01-01
Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and
Optimization

Michael Grigalunas, Tobias Ankner, Per-Ola Norrby, Olaf Wiest, Paul Helquist
Journal of the American Chemical Society - 2015-01-01
Theoretical and Experimental Optimization of a New Amino Phosphite Ligand Library for Asymmetric Palladium-Catalyzed Allylic
Substitution

M. Magre, M. Biosca, Per-Ola Norrby, O. Pamies, M. Dieguez
Chemcatchem - 2015-01-01
Pd-eta(3)-C6H9 complexes of the Trost modular ligand: high nuclearity columnar aggregation controlled by concentration, solvent and
counterion

D. T. Racys, J. Eastoe, Per-Ola Norrby, I. Grillo, S. E. Rogers, G. C. Lloyd-Jones
Chemical Science - 2015-01-01
Mechanistic Studies on the Alkylation of Amines with Alcohols Catalyzed by a Bifunctional Iridium
Complex

A. Bartoszewicz, G. G. Miera, R. Marcos, Per-Ola Norrby, B. Martin-Matute
Acs Catalysis - 2015-01-01
On the Radical Nature of Iron-Catalyzed Cross-Coupling
Reactions

Anna Hedström, Z. Izakian, Irma Vreto, Carl Johan Wallentin, Per-Ola Norrby
Chemistry-a European Journal - 2015-01-01
New insights into the mechanism of iron-catalyzed cross-coupling
reactions

Ahmadreza R. Bekhradnia, Per-Ola Norrby
Dalton Transactions - 2015-01-01
Improving the Q2MM Method for Transition State Force Field
Modeling

Elaine Limé, Per-Ola Norrby
Journal of Computational Chemistry - 2015-01-01
Mechanistic Aspects of Copper-Catalyzed
Reactions

Per-Fredrik Larsson, Per-Ola Norrby, S. Woodward
Copper-Catalyzed Asymmetric Synthesis - 2014-01-01
Mechanistic Investigations of Palladium-Catalyzed Allylic
Fluorination

Matthew H. Katcher, Per-Ola Norrby, Abigail G. Doyle
Organometallics - 2014-01-01
Role of the Base in Buchwald-Hartwig
Amination

Ylva Sunesson, E. Lime, S. O. N. Lill, R. E. Meadows, Per-Ola Norrby
Journal of Organic Chemistry - 2014-01-01
Mechanism, reactivity, and selectivity in palladium-catalyzed redox-relay heck arylations of alkenyl
alcohols

L. Xu, M. J. Hilton, X. Zhang, Per-Ola Norrby, Y. D. Wu, M. S. Sigman, O. Wiest
Journal of the American Chemical Society - 2014-01-01
Epoxyalcohols: bioactivation and conjugation required for skin
sensitization.

Tamara Delaine, David J. Ponting, Ida B Niklasson, Roger Emter, Lina Hagvall, Per-Ola Norrby, Andreas Natsch, Kristina Luthman, Ann-Therese Karlberg
Chemical research in toxicology - 2014-01-01
Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild
Conditions

M. Grigalunas, T. Ankner, Per-Ola Norrby, O. Wiest, P. Helquist
Organic Letters - 2014-01-01
Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone
Hydrogenation

Elaine Limé, Michelle D. Lundholm, Aaron Forbes, Olaf Wiest, Paul Helquist, Per-Ola Norrby
Journal of Chemical Theory and Computation - 2014-01-01
Fast and reversible insertion of carbon dioxide into zirconocene-alkoxide bonds. A mechanistic
study

A. Brink, I. Truedsson, A. Fleckhaus, M. T. Johnson, Per-Ola Norrby, A. Roodt, O. F. Wendt
Dalton Transactions - 2014-01-01
Mechanistic Aspects of Submol% Copper-Catalyzed C-N
Cross-Coupling

Per-Fredrik Larsson, Carl Johan Wallentin, Per-Ola Norrby
Chemcatchem - 2014-01-01
Breaking conjugation: Unusual regioselectivity with 2-substituted allylic substrates in the Tsuji-Trost
reaction

B. S. Kim, M. M. Hussain, Per-Ola Norrby, P. J. Walsh
Chemical Science - 2014-01-01
On the oxidation state of iron in iron-mediated C-C
couplings

Anna Hedström, Erik Lindstedt, Per-Ola Norrby
Journal of Organometallic Chemistry - 2013-01-01
Modeling in Homogeneous Catalysis: a
Tutorial

Eric Clot, Per-Ola Norrby
Innovative Catalysis in Organic Synthesis: Oxidation, Hydrogenation,and C-X Bond Forming Reactions, Ed: P. Andersson - 2012-01-01
Transmetallation Versus β-Hydride Elimination: The Role of 1,4-Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic
Acids

Christian Sköld, Jonatan Kleimark, Alejandro Trejos, Luke R. Odell, Sten O. Nilsson Lill, Per-Ola Norrby, Mats Larhed
Chemistry - A European Journal - 2012-01-01
Mechanistic Studies of the CuH-Catalyzed Synthesis of
α-Hydroxyallenes

Helene Reeker, Per-Ola Norrby, Norbert Krause
Organometallics - 2012-01-01
tBu or not
tBu?

Sten O. Nilsson Lill, Per Ryberg, Tobias Rein, Evelina Bennström, Per-Ola Norrby
Chemistry - A European Journal - 2012-01-01
Chelation-Controlled Addition of Organozincs to alpha-Chloro
Aldimines

G. R. Stanton, Per-Ola Norrby, P. J. Carroll, P. J. Walsh
Journal of the American Chemical Society - 2012-01-01
New efficient ligand for sub-mol % copper-catalyzed C-N cross-coupling reactions running under
air

Per-Fredrik Larsson, Peter Astvik, Per-Ola Norrby
Beilstein Journal of Organic Chemistry - 2012-01-01
Aggregation and Solvation of Chiral N,P-Amide Ligands in Coordinating Solvents: A Computational and NMR Spectroscopic
Study

Petra Rönnholm, Sten O. Nilsson Lill, Jürgen Gräfenstein, Per-Ola Norrby, Mariell Pettersson, Göran Hilmersson
Chempluschem - 2012-01-01
Mild and efficient nickel-catalyzed Heck reactions with electron-rich
olefins.

Thomas M Gøgsig, Jonatan Kleimark, Sten O. Nilsson Lill, Signe Korsager, Anders T Lindhardt, Per-Ola Norrby, Troels Skrydstrup
Journal of the American Chemical Society - 2012-01-01
Low Temperature Studies of Iron-Catalyzed Cross-Coupling of Alkyl Grignard Reagents with Aryl
Electrophiles

Jonatan Kleimark, Per-Fredrik Larsson, Parisa Emamy, Anna Hedström, Per-Ola Norrby
Advanced Synthesis & Catalysis - 2012-01-01
A computational study of the enantioselective addition of n-BuLi to benzaldehyde in the presence of a chiral lithium N,P
amide.

Petra Rönnholm, Jürgen Gräfenstein, Per-Ola Norrby, Göran Hilmersson, Sten O. Nilsson Lill
Organic & biomolecular chemistry - 2012-01-01
Computational Insights into Palladium-Mediated Allylic Substitution
Reactions

Jonatan Kleimark, Per-Ola Norrby
Topics in Organometallic Chemistry - 2012-01-01
Experimental and Theoretical Investigations of the Autoxidation of Geranial: A Dioxolane Hydroperoxide Identified as a Skin
Sensitizer.

Lina Hagvall, Carina Bäcktorp, Per-Ola Norrby, Ann-Therese Karlberg, Anna Börje
Chemical research in toxicology - 2011-01-01
Palladium-Catalyzed Allylic Sulfinylation and the Mislow-Braverman-Evans
Rearrangement.

Jonatan Kleimark, Guillaume Prestat, Giovanni Poli, Per-Ola Norrby
Chemistry - A European Journal - 2011-01-01
γ- and δ-lactams through palladium-catalyzed intramolecular allylic alkylation: enantioselective synthesis, NMR Investigation, and DFT
rationalization.

Xavier Bantreil, Guillaume Prestat, Aitor Moreno, David Madec, Peter Fristrup, Per-Ola Norrby, Paul S Pregosin, Giovanni Poli
Chemistry - A European Journal - 2011-01-01
A highly selective agonist for the metabotropic glutamate receptor
mGluR2

Simon D. Nielsen, Marica Fulco, Michaela Serpi, Birgitta Nielsen, Maria B. Hansen, Kasper L. Hansen, Christian Thomsen, Robb Brodbeck, Hans Bräuner-Osborne, Roberto Pellicciari, Per-Ola Norrby, Jeremy R. Greenwood, Rasmus P. Clausen
MedChemComm - 2011-01-01
Dispersion and Back-Donation Gives Tetracoordinate [Pd(PPh(3) )(4)
].

Mårten S G Ahlquist, Per-Ola Norrby
Angewandte Chemie (International ed. in English) - 2011-01-01
A DFT comparison of the neutral and cationic Heck
pathways.

Carina Bäcktorp, Per-Ola Norrby
Dalton transactions (Cambridge, England : 2003) - 2011-01-01
Iron-catalyzed coupling of aryl grignard reagents with alkyl halides: a competitive hammett
study.

Anna Hedström, Ulla Bollmann, Jenny Bravidor, Per-Ola Norrby
Chemistry (Weinheim an der Bergstrasse, Germany) - 2011-01-01
Pyranoside Phosphite-Oxazoline Ligands for the Highly Versatile and Enantioselective Ir-Catalyzed Hydrogenation of Minimally Functionalized Olefins. A Combined Theoretical and Experimental
Study.

Javier Mazuela, Per-Ola Norrby, Pher G Andersson, Oscar Pàmies, Montserrat Diéguez
Journal of the American Chemical Society - 2011-01-01
Sterically Governed Selectivity in Palladium-Assisted Allylic
Alkylation

Jonatan Kleimark, Charlotte Johansson, Susanne Olsson, Mikael Håkansson, Sverker Hansson, Björn Åkermark, Per-Ola Norrby
Organometalics - 2011-01-01
Application of Q2MM to Stereoselective
Reactions

Sten O. Nilsson Lill, Aaron Forbes, Patrick Donoghue, Vincenzo Verdolino, Olaf Wiest, Patrik Rydberg, Per-Ola Norrby
Current Organic Chemistry - 2010-01-01
Kinetic investigation of a ligand-accelerated sub-mol% copper-catalyzed C-N cross-coupling
reaction.

Per-Fredrik Larsson, Carsten Bolm, Per-Ola Norrby
Chemistry: A European Journal - 2010-01-01
On the mechanism of the rhodium catalyzed acrylamide
hydrogenation

Vincenzo Verdolino, Aaron Forbes, Paul Helquist, Per-Ola Norrby, Olaf Wiest
Journal of Molecular Catalysis A: Chemical - 2010-01-01
Editorial

Per-Ola Norrby, Guy C. Lloyd-Jones
Journal of Molecular Catalysis A: Chemical - 2010-01-01
alpha-Arylation by Rearrangement: On the Reaction of Enolates with Diaryliodonium
Salts.

Per-Ola Norrby, Tue B Petersen, Marcin Bielawski, Berit Olofsson
Chemistry - A European Journal - 2010-01-01
Memory and dynamics in Pd-catalyzed allylic alkylation with P,N-ligands Dedicated to Professor Henri Kagan on the occasion of his 80th
birthday

Charlotte Johansson, Guy C. Lloyd-Jones, Per-Ola Norrby
Tetrahedron: Asymmetry - 2010-01-01
DFT investigation of the palladium-catalyzed ene-yne
coupling.

Signe Teuber Henriksen, David Tanner, Troels Skrydstrup, Per-Ola Norrby
Chemistry - A European Journal - 2010-01-01
Interrogation of a dynamic multi-catalyst ensemble in asymmetric
catalysis

Julian Eastoe, Ian J. S. Fairlamb, Jesús M. Fernández-Hernández, Emane Filali, John C. Jeffery, Guy C. Lloyd-Jones, Aina Martorell, Antony Meadowcroft, Per-Ola Norrby, Thomas Riis-Johannessen, David A. Sale, Paula M. Tomlin
Faraday Discussions - 2010-01-01
Trans effects in the Heck reaction—A model
study

Carina Bäcktorp, Per-Ola Norrby
Journal of Molecular Catalysis A: Chemical - 2010-01-01
Copper-catalyzed cross-couplings with part-per-million catalyst
loadings.

Per-Fredrik Larsson, Arkaitz Correa, Monica Carril, Per-Ola Norrby, Carsten Bolm
Angewandte Chemie (International ed. in English) - 2009-01-01
Mechanistic Investigation of Iron-Catalyzed Coupling
Reactions

Jonatan Kleimark, Anna Hedström, Per-Fredrik Larsson, Charlotte Johansson, Per-Ola Norrby
ChemCatChem - 2009-01-01
DFT-Based Explanation of the Effect of Simple Anionic Ligands on the Regioselectivity of the Heck Arylation of Acrolein
Acetals

Signe Teuber Henriksent, David Tanner, Sandro Cacchi, Per-Ola Norrby
Organometallics - 2009-01-01
Structure-based rationale for selectivity in the asymmetric allylic alkylation of cycloalkenyl esters employing the Trost 'Standard Ligand' (TSL): isolation, analysis and alkylation of the monomeric form of the cationic eta(3)-cyclohexenyl complex
[(eta(3)-c-C6H9)Pd(TSL)]+.

Craig P Butts, Emane Filali, Guy C Lloyd-Jones, Per-Ola Norrby, David A Sale, York Schramm
Journal of the American Chemical Society - 2009-01-01
Prediction of enantioselectivity in rhodium catalyzed
hydrogenations.

Patrick J Donoghue, Paul Helquist, Per-Ola Norrby, Olaf Wiest
Journal of the American Chemical Society - 2009-01-01
Steric Influence on the Excited-State Lifetimes of Ruthenium Complexes with Bipyridyl−Alkanylene−Pyridyl
Ligands

Maria Abrahamsson, Maria J. Lundqvist, Henriette Wolpher, Olof Johansson, Lars Eriksson, Jonas Bergquist, Torben Rasmussen, Hans-Christian Becker, Leif Hammarström, Per-Ola Norrby, Björn Åkermark, Petter Persson
Inorganic Chemistry - 2008-01-01
Mechanisms of Air Oxidation of Ethoxylated Surfactants - Computational Estimations of Energies and Reaction
Behaviors

Carina Bäcktorp, Anna Börje, J. Lars. G Nilsson, Ann-Therese Karlberg, Per-Ola Norrby, Gunnar Nyman
Chemistry - A European Journal - 2008-01-01
Mechanism of Air Oxidation of the Fragrance Terpene
Geraniol

Carina Bäcktorp, Lina Hagvall, Anna Börje, Ann-Therese Karlberg, Per-Ola Norrby, Gunnar Nyman
J.Chem.Theory Comput. - 2008-01-01
On the Nature of the Intermediates and the Role of Chloride Ions in Pd-Catalyzed Allylic Alkylations: Added Insight from Density Functional
Theory.

Peter Fristrup, Mårten Ahlquist, David Tanner, Per-Ola Norrby
The journal of physical chemistry. A - 2008-01-01
Asymmetric Synthesis of Iridoid Derivatives Using Resolved 2-Phenylindoline as a Chiral
Auxiliary

Ellen M. Santangelo, IIme Liblikas, Anoma Mudalige, Karl W. Törnroos, Per-Ola Norrby, C. Rikard Unelius
European Journal of Organic Chemistry - 2008-01-01
Acid-Catalyzed Nucleophilic Aromatic Substitution: Experimental and Theoretical Exploration of a Multistep
Mechanism

Mårten Jacobsson, Jonas Oxgaard, Carl-Olof Abrahamsson, Per-Ola Norrby, William A. Goddard III, Ulf Ellervik
Chemistry - A European Journal - 2008-01-01
Transition-State Docking of Flunitrazepam and Progesterone in Cytochrome
P450

Patrik Rydberg, Sine Myrup Hansen, Jacob Kongsted, Per-Ola Norrby, Lars Olsen, Ulf Ryde
J.Chem.Theory Comput. - 2008-01-01
The Mechanism for the Rhodium-Catalyzed Decarbonylation of Aldehydes: A Combined Experimental and Theoretical
Study

Peter Fristrup, Michael Kreis, Anders Palmelund, Per-Ola Norrby, Robert Madsen
J.Am.Chem.Soc. - 2008-01-01
Development of a Q2MM Force Field for the Asymmetric Rhodium Catalyzed Hydrogenation of
Enamides

Patricks J Donoghue, Paul Helquist, Per-Ola Norrby, Olaf Wiest
J.Chem.Theory Comput - 2008-01-01
Unusual Selectivity-Determining Factors in the Phosphine-Free Heck Arylation of Allyl
Ethers

IIaria Ambrogio, Giancarlo Fabrizi, Sandro Cacchi, Signe Teuber Henriksen, Peter Fristrup, David Tanner, Per-Ola Norrby
Organometallics - 2008-01-01
Combined Experimental and Theoretical Study of the Mechanism and Enantioselectivity of Palladium- Catalyzed Intermolecular Heck
Coupling

Signe T. Henriksen, Per-Ola Norrby, Päivi Kaukoranta, Pher G. Andersson
J.Am.Chem.Soc - 2008-01-01
Memory Effects in Palladium-Catalyzed Allylic Alkylations of 2-Cyclohexen-1-yl
Acetate

Nina Svensen, Peter Fristrup, David Tanner, Per-Ola Norrby
Adv.Synth.Catal - 2007-01-01
Oxidative addition of aryl chlorides to monoligated palladium(0): A DFT-SCRF
study

Mårten Ahlquist, Per-Ola Norrby
Organometallics - 2007-01-01
General transition-state force field for cytochrome p450
Hydroxylation

Patrik Rydberg, Lars Olsen, Per-Ola Norrby, Ulf Ryde
Journal of Chemical Theory and Computation - 2007-01-01