Niklas Bergh
Universitetslektor, adjungerad
Department of Molecular and ClinicalAbout Niklas Bergh
Associate professor, Cardiologist Department of Cardiology Sahlgrenska University Hospital
Niklas Bergh is cardiologist at the division of Cardiology, Sahlgrenska University Hospital. His main interest is severe heart failure, heart transplantation, pulmonary arterial hypertension (PAH). He is currently Associate Professor in experimental Cardiology at the Department of Molecular and Clinical Medicine, University of Gothenburg. His team consists of a preclinical group mainly investigating the endogenous fibrinolytic system and the role of subendothelial fibrin deposits in the pathogenesis of atherosclerosis. The clinical part of the group focus on the pathogenesis of different cardiomyopathies, mainly dilated and hyperthrophic cardiomyopathy, DCM/HCM.
Group members
- Entela Bollano, MD, PhD, senior scientist
- Per Fogelstrand, PhD senior scientist
- Pia Larsson, PhD, senior scientist
- Lars Glise, PhD student
Key Publications
- Saluveer O, Redfors B, Angerås O, Dworeck C, Haraldsson I, Ljungman C, Petursson P, Odenstedt J, Ioanes D, Lundgren P, Völz S, Råmunddal T, Andersson B, Omerovic E, Bergh N. Hypertension is associated with increased mortality in patients with ischemic heart disease after revascularization with percutaneous coronary intervention – a report from SCAAR. Blood Press. 26(3):166-173. (2017)
- Larsson P, Alwis I, Niego B, Sashindranath M, Fogelstrand P, Wu MC, Glise L, Magnusson M, Daglas M, Bergh N, Jackson SP, Medcalf RL, Jern S. J Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse. Thromb Haemost. doi: 10.1111/jth.13527. (2016)
- Magnusson M, Larsson P, Lu EX, Bergh N, Carén H, Jern S. Rapid and specific hypomethylation of enhancers in endothelial cells during adaptation to cell culturing. Epigenetics. 11(8):614-24. doi: 10.1080/15592294.2016.1192734. (2016)
- Svennerholm K, Larsson P, Ulfhammer E, Omerovic E, Biber B, Jern S, Haney M, Bergh N. Histone deacetylase inhibition enhances tissue plasminogen activator release in man with atherosclerotic disease. PloS One 10(3):e0121196. PONE-D-14-39552R1. (2015)
- Spanos E, Karlsson L, Redfors B, Yangzhen S, Omerovic E, Bobrova I, Grip L, Bergh N. Cardioprotection of the enkephalin analogue Eribis peptide 94 in a rat model of ischemia and reperfusion is highly dependent on dosing regimen and timing of administration. Pharmacol. 29;747C:1-6. (2014)
- Saluveer O, Larsson P, Riddarstråle W; Hrafnkelsdottir T, Jern S, Bergh N. Profibrinolytic effect of the epigenetic modifier valproic acid in man. PLoS One. 8;9(10)e107582. (2014)
- Svennerholm K, Bergh N, Larsson P, Jern S, Johansson G, Biber B, Haney M. Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model. PLoS One, 12;9(5):E97260. (2014)
- Bergh N, Angerås O, Albertsson P, Dworeck C, Matejka G, Haraldsson I, Ioanes D, Libungan B, Odenstedt J, Petursson P, Ridderstråle W, Råmunddal T, Omerovic E. Effects of Intra-Aortic Balloon Counterpulsation Support Commenced Before or After Primary Percutaneous Coronary Intervention in Cardiogenic Shock Due to ST-Elevation Myocardial Infartion. Acute Card Care.16(2):57-62. doi: 10.3109/17482941.2014.881504.(2014)
- Larsson P, Bergh N, Ulfhammer E, Magnusson M, Wåhlander K, Karlsson L, Jern S. Histone Deacetylase Inhibitors Potently Stimulate Tissue-type Plasminogen Activator Production in Vascular Endothelial Cells. J Thromb Thrombolysis. 35(2):185-92. (2013)
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Echocardiography in inflammatory heart disease: A comparison of giant cell myocarditis, cardiac sarcoidosis, and acute non-fulminant
myocarditis
Emanuele Bobbio, Johanna Amundsen, Anders Oldfors, Entela Bollano, Niklas Bergh, Marie Björkenstam, Marco Astengo, Kristjan Karason, Sinsia A Gao, Christian Lars Polte
IJC Heart and Vasculature - 2023 -
Differences in phenotypes, symptoms, and survival in patients with cardiomyopathy-a prospective observational study from the Sahlgrenska CardioMyoPathy
Centre.
Charlotta Ljungman, Entela Bollano, Araz Rawshani, Charlotte Nordberg Backelin, Pia Dahlberg, Inger Valeljung, Marie Björkenstam, Clara Hjalmarsson, Michael Fu, Tomas Mellberg, Sven-Erik Bartfay, Christian Lars Polte, Bert Andersson, Niklas Bergh
Frontiers in cardiovascular medicine - 2023 -
Cardiac sarcoidosis and giant cell myocarditis after COVID-19
infection.
Entela Bollano, Christian Lars Polte, Mikko I Mäyränpää, Anders Oldfors, Niklas Bergh, Jukka Lehtonen, Riina Kandolin
ESC heart failure - 2022 -
Incidental cardiac findings on somatostatin receptor PET/CT: What do they indicate and are they of clinical
relevance?
Emanuele Bobbio, Anna Dudás, Anders Bergström, Daniela Esposito, Oskar Angerås, Amar Taha, Martijn van Essen, Marie Björkenstam, Kristjan Karason, Entela Bollano, Niklas Bergh, Christian Lars Polte
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 2022 -
Risk of Heart Failure in Congenital Heart Disease: A Nationwide Register-based Cohort
Study.
Niklas Bergh, Kristofer Skoglund, Maria Fedchenko, Entela Bollano, Peter J Eriksson, Mikael Dellborg, Kok Wai Giang, Zacharias Mandalenakis
Circulation - 2022 -
Efficacy and safety of clopidogrel versus ticagrelor as part of dual antiplatelet therapy in acute coronary syndrome - a systematic review and
meta-analysis.
Niklas Bergh, Anna Myredal, Per Nivedahl, Max Petzold, Sultan Zarin, Constanze Wartenberg, Susanna Maria Wallerstedt
Journal of cardiovascular pharmacology - 2022 -
Prehospital monitoring of cerebral circulation during out of hospital cardiac arrest ? A feasibility
study.
Anna Henningsson, Lukas Lannemyr, Oskar Angerås, Joakim Björås, Niklas Bergh, Johan Herlitz, Bengt Redfors, Peter Lundgren
Scandinavian journal of trauma, resuscitation and emergency medicine - 2022 -
Case report of eosinophilic granulomatosis with polyangitis presenting as acute
myocarditis.
Marie Björkenstam, Emanuele Bobbio, Tomas Mellberg, Christian Lars Polte, Niklas Bergh, Francesco Giallauria, Entela Bollano
Clinical case reports - 2022 -
Association between central haemodynamics and renal function in advanced heart failure: a nationwide study from
Sweden.
Emanuele Bobbio, Entela Bollano, Christian Lars Polte, Jan Ekelund, Göran Rådegran, Jakob Lundgren, Carl Haggård, Grunde Gjesdal, Oscar Braun, Sven-Erik Bartfay, Niklas Bergh, Pia Dahlberg, Clara Hjalmarsson, Sorosh Esmaily, Ida Haugen Löfman, Aristomenis Manouras, Michael Melin, Göran Dellgren, Kristjan Karason
ESC heart failure - 2022 -
The association between signs of medical distress preceding in-hospital cardiac arrest and 30-day survival - A register-based cohort
study.
Meena Thuccani, Araz Rawshani, Kristofer Skoglund, Niklas Bergh, Per Nordberg, Malin Albert, Annika Rosengren, Johan Herlitz, Christian Rylander, Peter Lundgren
Resuscitation plus - 2022 -
Phenotypic and HLA-DRB1 allele characterization of Swedish cardiac sarcoidosis
patients.
Per Eldhagen, Emanuele Bobbio, Pernilla Darlington, Johan Grunewald, Anders Eklund, Christian Lars Polte, Niklas Bergh, Entela Bollano, Peder Sörensson, Susanna Kullberg
International journal of cardiology - 2022 -
Diagnosis, management, and outcome of cardiac sarcoidosis and giant cell myocarditis: a Swedish single center
experience.
Emanuele Bobbio, Clara Hjalmarsson, Marie Björkenstam, Christian Lars Polte, Anders Oldfors, Ulf Lindström, Pia Dahlberg, Sven-Erik Bartfay, Piotr Szamlewski, Amar Taha, Egidija Sakiniene, Kristjan Karason, Niklas Bergh, Entela Bollano
BMC cardiovascular disorders - 2022 -
Somatostatin receptor positron emission tomography/computed tomography in myocarditis following mRNA COVID-19
vaccination.
Entela Bollano, Niklas Bergh, Anna Dudás, Emanuele Bobbio, Christian Lars Polte
European heart journal. Case reports - 2022 -
Cardiovascular Magnetic Resonance in
Myocarditis.
Christian Lars Polte, Emanuele Bobbio, Entela Bollano, Niklas Bergh, Christina Polte, Jakob Himmelman, Kerstin M Lagerstrand, Sinsia A Gao
Diagnostics (Basel, Switzerland) - 2022 -
Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myocarditis: a systematic review and
meta-analysis.
Emanuele Bobbio, Marie Björkenstam, Bright I Nwaru, Francesco Giallauria, Eva Hessman, Niklas Bergh, Christian Lars Polte, Jukka Lehtonen, Kristjan Karason, Entela Bollano
Clinical research in cardiology : official journal of the German Cardiac Society - 2022 -
Somatostatin Receptor Positron Emission Tomography/Computed Tomography in Giant Cell Myocarditis: A Promising Approach to Molecular Myocardial Inflammation
Imaging.
Christian Lars Polte, Entela Bollano, Anders Oldfors, Anna Dudàs, Kerstin M Lagerstrand, Jakob Himmelman, Emanuele Bobbio, Kristjan Karason, Martijn van Essen, Niklas Bergh
Circulation. Cardiovascular imaging - 2022 -
Cardiac involvement in immune-mediated necrotizing myopathy: insights from CMR and somatostatin receptor
PET/CT.
Christian Lars Polte, Niklas Bergh, Anders Oldfors, Hanna Balsam, Entela Bollano
European heart journal. Cardiovascular Imaging - 2021 -
Grading right ventricular dysfunction in left ventricular disease using echocardiography: a proof of concept using a novel multiparameter
strategy.
Odd Bech-Hanssen, Marco Astengo, Martin Fredholm, Niklas Bergh, Clara Hjalmarsson, Christian Lars Polte, Sven-Erik Ricksten, Entela Bollano
ESC heart failure - 2021 -
Brain organoid formation on decellularized porcine brain ECM
hydrogels.
Robin Simsa, Theresa Rothenbucher, Hakan Gurbuz, Nidal Ghosheh, Jenny Emneus, Lachmi Jenndahl, David L Kaplan, Niklas Bergh, Alberto Martinez Serrano, Per Fogelstrand
PloS one - 2021 -
Invasive haemodynamics in de novo everolimus vs. calcineurin inhibitor heart transplant
recipients.
Niklas Bergh, Einar Gude, Sven-Erik Bartfay, K Andereassen A, Satish Arora, Pia Dahlberg, Göran Dellgren, Lars Gullestad, Finn Gustafsson, Kristjan Karason, Göran Rådegran, Entela Bollano, Bert Andersson
ESC heart failure - 2020 -
Effect of fluid dynamics on decellularization efficacy and mechanical properties of blood
vessels
Robin Simsa, X. M. Vila, E. Salzer, A. Teuschl, L. Jenndahl, Niklas Bergh, Per Fogelstrand
PLoS ONE - 2019 -
Cardiac arrest in Wilson's disease after curative liver transplantation: a life-threatening complication of myocardial copper
excess?
Niklas Forsgard, Anders Oldfors, Entela Bollano, Bert Andersson, Niklas Bergh, Kristjan Karason, Christian Lars Polte
ESC Heart Failure - 2019 -
Disturbed Laminar Blood Flow Causes Impaired Fibrinolysis and Endothelial Fibrin Deposition In
Vivo.
Lars Glise, Pia Larsson, Sverker Jern, Jan Borén, Malin Levin, Tor Ny, Per Fogelstrand, Niklas Bergh
Thrombosis and haemostasis - 2019 -
Endothelial repair is dependent on CD11c(+) leukocytes to establish regrowing endothelial sheets with high cellular
density
Ulf Yrlid, Maricris Holm, Malin Levin, Samuel Alsén, Malin Lindbom, Lars Glise, Niklas Bergh, Jan Borén, Per Fogelstrand
Journal of Leukocyte Biology - 2019 -
Systematic in vitro comparison of decellularization protocols for blood
vessels.
Robin Simsa, Arvind M. Padma, Heher P, Mats Hellström, Teuschl A, Lachmi Jenndal, Niklas Bergh, Per Fogelstrand
PloS one - 2018 -
Hypertension is associated with increased mortality in patients with ischaemic heart disease after revascularization with percutaneous coronary intervention - a report from
SCAAR.
Ott Saluveer, Björn Redfors, Oskar Angerås, Christian Dworeck, Inger Haraldsson, Charlotta Ljungman, Petur Petursson, Jacob Odenstedt, Dan Ioanes, Peter Lundgren, Sebastian Völz, Truls Råmunddal, Bert Andersson, Elmir Omerovic, Niklas Bergh
Blood pressure - 2017 -
Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the
mouse.
Pia Larsson, I Alwis, B Niego, M Sashindranath, Per Fogelstrand, M C L Wu, Lars Glise, Mia Magnusson, M Daglas, Niklas Bergh, S P Jackson, R L Medcalf, Sverker Jern
Journal of thrombosis and haemostasis : JTH - 2016 -
Rapid and specific hypomethylation of enhancers in endothelial cells during adaptation to cell
culturing.
Mia Magnusson, Pia Larsson, Emma Xuchun Lu, Niklas Bergh, Helena Carén, Sverker Jern
Epigenetics - 2016 -
Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of
t-PA.
Erik Ulfhammer, Pia Larsson, Mia Magnusson, Lena M S Carlsson, Niklas Bergh, Sverker Jern
International journal of vascular medicine - 2016 -
Cardioprotection of the enkephalin analog Eribis peptide 94 in a rat model of ischemia and reperfusion is highly dependent on dosing regimen and timing of
administration
Elias Spanos, Lars O Karlsson, Björn Redfors, Yangzhen Shao, Elmir Omerovic, Irina Bobrova, Lars Grip, Niklas Bergh
European Journal of Pharmacology - 2015 -
Correction: Histone Deacetylase Inhibition Enhances Tissue Plasminogen Activator Release Capacity in Atherosclerotic
Man.
Kristina Svennerholm, Michael Haney, Björn Biber, Erik Ulfhammer, Ott Saluveer, Pia Larsson, Elmir Omerovic, Sverker Jern, Niklas Bergh
PloS one - 2015 -
Dynamic Enhancer Methylation - A Previously Unrecognized Switch for Tissue-Type Plasminogen Activator
Expression.
Mia Magnusson, Emma Xuchun Lu, Pia Larsson, Erik Ulfhammer, Niklas Bergh, Helena Carén, Sverker Jern
PloS one - 2015 -
Histone deacetylase inhibition enhances tissue plasminogen activator release capacity in atherosclerotic
man.
Kristina Svennerholm, Michael Haney, Björn Biber, Erik Ulfhammer, Ott Saluveer, Pia Larsson, Elmir Omerovic, Sverker Jern, Niklas Bergh
PloS one - 2015 -
Profibrinolytic effect of the epigenetic modifier valproic Acid in
man.
Ott Saluveer, Pia Larsson, Wilhelm Ridderstråle, Thordis Hrafnkelsdottir, Sverker Jern, Niklas Bergh
PloS one - 2014 -
Histone Deacetylase Inhibitor Treatment Increases Coronary t-PA Release in a Porcine Ischemia
Model.
Kristina Svennerholm, Niklas Bergh, Pia Larsson, Sverker Jern, Göran Johansson, Björn Biber, Michael Haney
PloS one - 2014 -
Does the timing of treatment with intra-aortic balloon counterpulsation in cardiogenic shock due to ST-elevation myocardial infarction affect
survival?
Niklas Bergh, Oskar Angerås, Per Albertsson, Christian Dworeck, Göran Matejka, Inger Haraldsson, Dan Ioanes, Berglind Libungan, Jacob Odenstedt, Petur Petursson, Wilhelm Ridderstråle, Truls Råmunddal, Elmir Omerovic
Acute cardiac care - 2014 -
Acute vascular effects of atorvastatin in hypertensive men: a pilot
study.
Ott Saluveer, Niklas Bergh, Ludger Grote, Ove Andersson, Thordis Hrafnkelsdottir, Bengt R Widgren
Scandinavian cardiovascular journal : SCJ - 2013 -
Histone deacetylase inhibitors stimulate tissue-type plasminogen activator production in vascular endothelial
cells.
Pia Larsson, Niklas Bergh, Emma Lu, Erik Ulfhammer, Mia Magnusson, Karin Wåhlander, Lena Karlsson, Sverker Jern
Journal of thrombosis and thrombolysis - 2013 -
Cyclosporine A, 2.5 mg/kg, Does Not Reduce Myocardial Infarct Size in a Porcine Model of Ischemia and
Reperfusion
Lars O Karlsson, Niklas Bergh, Lars Grip
Journal of cardiovascular pharmacology and therapeutics - 2012 -
Effect of shear stress, statins and TNF-alpha on hemostatic genes in human endothelial
cells
Niklas Bergh, Pia Larsson, Erik Ulfhammer, Sverker Jern
Biochemical and biophysical research communications - 2012 -
Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and
reperfusion
Lars O Karlsson, Niklas Bergh, Lizhen Li, E. Bissessar, I. Bobrova, G. J. Gross, Levent Akyürek, Lars Grip
European journal of pharmacology - 2012 -
Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator
expression
Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, S. Lunke, A. El-Osta, R. L. Medcalf, Per-Arne Svensson, Lena Karlsson, Sverker Jern
PloS one - 2012 -
Suppression of endothelial t-PA expression by prolonged high laminar shear
stress
Erik Ulfhammer, Maria Carlström, Niklas Bergh, Pia Larsson, Lena Karlsson, Sverker Jern
Biochemical and Biophysical Research Communications - 2009 -
Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular
endothelium
Niklas Bergh
2009 -
Effects of two complex hemodynamic stimulation profiles on hemostatic genes in a vessel-like
environment
Niklas Bergh, Erik Ulfhammer, Lena Karlsson, Sverker Jern
Endothelium - 2008 -
Brist på tid och pengar hindrar läkarstuderande från att
forska
Daniel Giglio, Niklas Bergh
Läkartidningen - 2008 -
A new biomechanical perfusion system for ex vivo study of small biological intact
vessels
Niklas Bergh, Mikael Ekman, Erik Ulfhammer, Maria Andersson, Lena Karlsson, Sverker Jern
Ann Biomed Eng - 2005