Michael Ashton
-
Chiral Chromatographic Isolation on Milligram Scale of the Human African Trypanosomiasis Treatment D- and
L-Eflornithine.
Mikael Boberg, Anna C Jonson, Hanna Leek, Rasmus Jansson Löfmark, Michael Ashton
ACS omega - 2020-01-01 -
Model-Based Assessment of Variability in Isoniazid Pharmacokinetics and Metabolism in Patients Co-Infected With Tuberculosis and HIV: Implications for a Novel Dosing
Strategy
Jesper Sundell, E. Bienvenu, D. Janzen, Sofia Birgersson, Angela Äbelö, Michael Ashton
Clinical Pharmacology & Therapeutics - 2020-01-01 -
Population Pharmacokinetics and Pharmacogenetics of Ethambutol in Adult Patients Coinfected with Tuberculosis and
HIV
Jesper Sundell, E. Bienvenu, Sofia Birgersson, Angela Äbelö, Michael Ashton
Antimicrobial Agents and Chemotherapy - 2020-01-01 -
Neural correlates of the DMT experience assessed with multivariate
EEG
C. Timmermann, L. Roseman, M. Schartner, R. Milliere, L. T. J. Williams, D. Erritzoe, S. Muthukumaraswamy, Michael Ashton, Adam Bendrioua, O. Kaur, S. Turton, M. M. Nour, C. M. Day, R. Leech, D. J. Nutt, R. L. Carhart-Harris
Scientific Reports - 2019-01-01 -
Simultaneous quantification of four first line antitubercular drugs and metabolites in human plasma by hydrophilic interaction chromatography and tandem mass
spectrometry
Jesper Sundell, E. Bienvenu, Sofia Birgersson, Angela Äbelö, Michael Ashton, Kurt-Jürgen Hoffmann
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences - 2019-01-01 -
Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic
meta-analysis
F. Kloprogge, L. Workman, S. Borrmann, M. Tekete, G. Lefevre, K. Hamed, P. Piola, J. Ursing, P. E. Kofoed, A. Martensson, B. Ngasala, A. Bjorkman, Michael Ashton, Sofia Friberg Hietala, F. Aweeka, S. Parikh, L. Mwai, T. M. E. Davis, H. Karunajeewa, S. Salman, F. Checchi, C. Fogg, P. N. Newton, M. Mayxay, P. Deloron, J. F. Faucher, F. Nosten, E. A. Ashley, R. McGready, M. van Vugt, S. Proux, R. N. Price, J. Karbwang, F. Ezzet, R. Bakshi, K. Stepniewska, N. J. White, P. J. Guerin, K. I. Barnes, J. Tarning
Plos Medicine - 2018-01-01 -
Inhibition of CYP3A by Antimalarial Piperaquine and Its Metabolites in Human Liver Microsomes With IVIV
Extrapolation
Mohd Yusmaidie Aziz, Kurt-Jürgen Hoffmann, Michael Ashton
Journal of Pharmaceutical Sciences - 2018-01-01 -
LC-MS/MS quantitation of antimalarial drug piperaquine and metabolites in human
plasma
Mohd Yusmaidie Aziz, Kurt-Jürgen Hoffmann, Michael Ashton
Journal of chromatography. B - 2017-01-01 -
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial
therapy
K. Vos, C. Lo Sciuto, R. Piedade, Michael Ashton, A. Bjorkman, B. Ngasala, A. Martensson, J. P. Gil
Pharmacogenomics - 2017-01-01 -
Population pharmacokinetic properties of artemisinin in healthy male Vietnamese
volunteers
Sofia Birgersson, P. V. Toi, N. T. Truong, N. T. Dung, Michael Ashton, T. T. Hien, Angela Abelö, Joel Tärning
Malaria Journal - 2016-01-01 -
Artemether-lumefantrine coadministration with antiretrovirals; population pharmacokinetics and dosing
implications
Richard Höglund, Pauline Byakika‐Kibwika, Mohammed Lamorde, Concepta Merry, Michael Ashton, Nicholas Philip John Day, Nicholas J White, Angela Abelö, Joel Tärning
British Journal of Clinical Pharmacology - 2015-01-01 -
Enantiospecific Reassessment of the Pharmacokinetics and Pharmacodynamics of Oral Eflornithine against Late-Stage Trypanosoma brucei gambiense Sleeping
Sickness
Rasmus Jansson Löfmark, K. Na-Bangchang, S. Bjorkman, F. Doua, Michael Ashton
Antimicrobial Agents and Chemotherapy - 2015-01-01 -
The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV
patients
Emile Bienvenu, Marelize Swart, Collet Dandara, Michael Ashton
Antiviral Research - 2014-01-01 -
Population pharmacokinetics of artesunate and dihydroartemisinin during long-term oral administration of artesunate to patients with metastatic breast
cancer.
Therese Ericsson, Antje Blank, Cornelia von Hagens, Michael Ashton, Angela Abelö
European Journal of Clinical Pharmacology - 2014-01-01 -
A high-throughput LC-MS/MS assay for quantification of artesunate and its metabolite dihydroartemisinin in human plasma and
saliva.
Sofia Birgersson, Therese Ericsson, Antje Blank, Cornelia von Hagens, Michael Ashton, Kurt-Jürgen Hoffmann
Bioanalysis - 2014-01-01 -
Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination
therapies.
Therese Ericsson, Jesper Sundell, Angelica Torkelsson, Kurt-Jürgen Hoffmann, Michael Ashton
Xenobiotica - 2014-01-01 -
Population pharmacokinetic modeling and deconvolution of enantioselective absorption of eflornithine in the
rat.
Carl-Christer Johansson, Peter Gennemark, Per Artursson, Angela Abelö, Michael Ashton, Rasmus Jansson Löfmark
Journal of pharmacokinetics and pharmacodynamics - 2013-01-01 -
Frequencies of Single Nucleotide Polymorphisms in Cytochrome P450 Genes in a Rwandan Population: Difference to Other African
Populations
Emile Bienvenu, Swart Marelize, Dandara Collet, Wonkam Ambroise, Agneta Ekman, Angela Abelö, Michael Ashton
Current Pharmacogenomics and Personalized Medicine - 2013-01-01 -
A rapid and selective HPLC-UV method for the quantitation of efavirenz in plasma from patients on concurrent HIV/AIDS and tuberculosis
treatments.
Emile Bienvenu, Kurt-Jürgen Hoffmann, Michael Ashton, Pierre Claver Kayumba
Biomedical chromatography : BMC - 2013-01-01 -
External Validation of the Bilirubin-Atazanavir Nomogram for Assessment of Atazanavir Plasma Exposure in HIV-1-Infected
Patients.
Dinko Rekić, Daniel Röshammar, Martin Bergstrand, Joel Tärning, Andrea Calcagno, Antonio D'Avolio, Vidar Ormaasen, Marie Vigan, Aurélie Barrail-Tran, Michael Ashton, Magnus Gisslén, Angela Abelö
The AAPS journal - 2013-01-01 -
The Evaluation of CYP2B6 Inhibition by Artemisinin Antimalarials in Recombinant Enzymes and Human Liver
Microsomes.
Therese Ericsson, Collen Masimirembwa, Angela Abelö, Michael Ashton
Drug metabolism letters - 2012-01-01 -
PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by
artemisinin.
Rita Piedade, Elke Schaeffeler, Stefan Winter, Sara Asimus, Matthias Schwab, Michael Ashton, Oliver Burk, José P Gil
Antimicrobial agents and chemotherapy - 2012-01-01 -
A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in
Sudan.
Richard Höglund, Ishag Adam, Warunee Hanpithakpong, Michael Ashton, Niklas Lindegardh, Nicholas Pj Day, Nicholas J White, Francois Nosten, Joel Tarning
Malaria journal - 2012-01-01 -
Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naïve HIV-1 infected
patients.
Daniel Röshammar, Ulrika S H Simonsson, Håkan Ekvall, Leo Flamholc, Vidar Ormaasen, Jan Vesterbacka, Eva Wallmark, Michael Ashton, Magnus Gisslén
Journal of pharmacokinetics and pharmacodynamics - 2011-01-01 -
In silico prediction of efavirenz and rifampicin drug-drug interaction considering weight and CYP2B6
phenotype
Dinko Rekić, Daniel Röshammar, Jackson Mukonzo, Michael Ashton
British Journal of Clinical Pharmacology - 2011-01-01 -
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in
plasma
TT Cloete, Carl C. Johansson, DD N'Da, SK Vodnala, ME Rottenberg, JC Breytenbach, Michael Ashton
Arzneimittelforschung Drug Research - 2011-01-01 -
HIV/AIDS Patients Display Lower Relative Bioavailability of Efavirenz than Healthy
Subjects.
Jackson K Mukonzo, Sarah Nanzigu, Dinko Rekić, Paul Waako, Daniel Röshammar, Michael Ashton, Jasper Ogwal-Okeng, Lars L Gustafsson, Eleni Aklillu
Clinical pharmacokinetics - 2011-01-01 -
Bilirubin-a potential marker of drug exposure in atazanavir-based antiretroviral
therapy.
Dinko Rekić, Oskar Clewe, Daniel Röshammar, Leo Flamholc, Anders Sönnerborg, Vidar Ormaasen, Magnus Gisslén, Angela Abelö, Michael Ashton
The AAPS journal - 2011-01-01 -
Orally formulated artemisinin in healthy fasting vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover
study.
Tran Tinh Hien, Warunee Hanpithakpong, Nguyen Thanh Truong, Nguyen Thi Dung, Pham Van Toi, Jeremy Farrar, Niklas Lindegardh, Joel Tärning, Michael Ashton
Clinical therapeutics - 2011-01-01 -
Determination of eflornithine enantiomers in plasma by precolumn derivatization with o-phthalaldehyde-N-acetyl-l-cysteine and liquid chromatography with UV
detection
Rasmus Jansson Löfmark, S Römsing, Eva Albers, Michael Ashton
BMC. Biomedical chromotography - 2010-01-01 -
Effects of oral administration of synthesized delta-amides of eflornithine in the
rat
Kevin J. Helena, David D. N''Da, Carl C. Johansson, Jaco C. Breytenbach, Michael Ashton
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH - 2010-01-01 -
Population pharmacokinetics and pharmacodynamics of artemether and lumefantrine during combination treatment in children with uncomplicated falciparum malaria in
Tanzania
Sofia Friberg Hietala, Andreas Mårtensson, Billy Ngasala, Sabina Dahlström, Niklas Lindegårdh, Anna Annerberg, Zul Premji, Anna Färnert, Pedro Gil, Anders Björkman, Michael Ashton
Antimicrobial agents and chemotherapy - 2010-01-01 -
Artemisinin--a possible CYP2B6 probe
substrate?
Sara Asimus, Michael Ashton
Biopharmaceutics & drug disposition - 2009-01-01 -
Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass
spectrometry.
N Lindegardh, J Tarning, P V Toi, T T Hien, J Farrar, P Singhasivanon, N J White, Michael Ashton, N P J Day
Journal of pharmaceutical and biomedical analysis - 2009-01-01 -
Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in
Vietnam.
M I Veiga, Sara Asimus, P E Ferreira, J P Martins, I Cavaco, V Ribeiro, T N Hai, Max Petzold, A Björkman, Michael Ashton, J P Gil
European journal of clinical pharmacology - 2009-01-01 -
Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in
Thailand.
Joel Tärning, EA Ashley, Niklas Lindegardh, K Stepniewska, L Phaiphun, NP Day, R McGready, Michael Ashton, F Nosten, NJ White
Antimicrobial Agents and Chemotherapy - 2008-01-01 -
Enantioselective and nonlinear intestinal absorption of eflornithine in the
rat.
Rasmus Jansson, Mikaela Malm, Christina Roth, Michael Ashton
Antimicrobial Agents and Chemotherapy - 2008-01-01 -
The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese
volunteers.
Trinh Ngoc Hai, Sofia Friberg Hietala, Nguyen Van Huong, Michael Ashton
Acta tropica - 2008-01-01 -
Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with
lipophilicity
Rasmus Jansson, Ulf Bredberg, Michael Ashton
Journal of Pharmaceutical Sciences - 2008-01-01 -
Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the
rat.
Joel Tärning, N Lindegårdh, Sofia Sandberg, NJP Day, NJ White, Michael Ashton
Journal of pharmaceutical sciences - 2008-01-01 -
A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination
regimens.
Doaa A Elsherbiny, Sara Asimus, Mats O Karlsson, Michael Ashton, Ulrika S H Simonsson
Journal of pharmacokinetics and pharmacodynamics - 2008-01-01 -
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy
subjects
Sara Asimus, D Elsherbiny, TN Hai, B Jansson, NV Huong, Max Petzold, USH Simonsson, Michael Ashton
Fundamental & Clinical Pharmacology - 2007-01-01 -
Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum
malaria
Sofia Friberg Hietala, Achuyt Bhattarai, Mwinyi Msellem, Daniel Röshammar, Abdullah S. Ali, Johan Strömberg, Francis W. Hombhanje, Akira Kaneko, Anders Björkman, Michael Ashton
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS - 2007-01-01 -
High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in
Zimbabwe.
C Nyakutira, Daniel Röshammar, E Chigutsa, P Chonzo, Michael Ashton, C Nhachi, C Masimirembwa
European Journal of Clinical Pharmacology - 2007-01-01 -
Artemisinin and CYP2A6 activity in healthy
subjects.
Sara Asimus, TN Hai, NV Huong, Michael Ashton
European Journal of Clinical Pharmacology - 2007-01-01 -
The Vietnamese Khin population harbours particular N-acetyltransferase 2
allele
frequencies.
I Cavaco, Sara Asimus, M Peyrard-Janvid, PE Ferreira, MI Veiga, TN Hai, V Ribeiro, Michael Ashton, JP Gil
Clinical Chemistry - 2007-01-01 -
Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male
subjects.
Daniel Röshammar, Trinh Ngoc Hai, Sofia Friberg Hietala, Nguyen Van Huong, Michael Ashton
European journal of clinical pharmacology - 2006-01-01 -
Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male
subjects
Daniel Röshammar, TN Hai, Sofia Friberg Hietala, N Van Huong, Michael Ashton
Eur J Clin Pharmacol - 2006-01-01 -
Development and validation of an automated solid phase extraction and liquid chromatographic method for the determination of piperaquine in
urine
Joel Tärning, T Singtoroj, A Annerberg, Michael Ashton, Y Bergqvist, NJ White, NP Day, N Lindegårdh
J Pharm Biomed Anal - 2006-01-01 -
A new approach to evaluate regression models during validation of bioanalytical
assays
T Singtoroj, Joel Tärning, A Annerberg, Michael Ashton, Y Bergqvist, NJ White, N Lindegårdh, NP Day
J Pharm Biomed Anal - 2006-01-01 -
Characterization of human urinary metabolites of the antimalarial
piperaquine
Joel Tärning, Y Bergqvist, N Day, J Bergquist, B Arvidsson, NJ White, Michael Ashton, N Lindegårdh
Drug Metabolism and Disposition - 2006-01-01 -
A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic
extraction
T Gordi, R Xie, NV Huong, DX Huong, MO Karlsson, Michael Ashton
Br J Clin Pharmacol. - 2005-01-01 -
Pitfalls in estimating piperaquine
elimination
Joel Tärning, N Lindegårdh, A Annerberg, T Singtoroj, NP Day, Michael Ashton, NJ White
Antimicrob Agents Chemother - 2005-01-01 -
Safety and tolerability of high-dose angiotensin receptor blocker therapy in patients with chronic kidney disease: a pilot
study
AJ Weinberg, DH Zappe, Michael Ashton, MS Weinberg
Am J Nephrol - 2004-01-01 -
Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid
chromatography.
Britt Jansson, Ulrika S H Simonsson, Michael Ashton
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 2003-01-01 -
Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not
2C9.
Ulrika S H Simonsson, Britt Jansson, Trinh Ngoc Hai, Dinh Xuan Huong, Gunnel Tybring, Michael Ashton
Clinical pharmacology and therapeutics - 2003-01-01 -
Automated solid-phase extraction method for the determination of piperaquine in whole blood by rapid liquid
chromatography.
N Lindegårdh, Michael Ashton, Y Bergqvist
Therapeutic drug monitoring - 2003-01-01 -
Automated solid-phase extraction method for the determination of piperaquine in plasma by peak compression liquid
chromatography.
N Lindegårdh, Michael Ashton, Y Bergqvist
Journal of chromatographic science - 2003-01-01 -
Characterisation of the human liver in vitro metabolic pattern of artemisinin and auto-induction in the rat by use of nonlinear mixed effects
modelling.
Ulrika S H Svensson, Mika Mäki-Jouppila, Kurt-Jürgen Hoffmann, Michael Ashton
Biopharmaceutics & drug disposition - 2003-01-01 -
Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage
regimens.
Toufigh Gordi, Dinh Xuan Huong, Trinh Ngoc Hai, Nguyen Thi Nieu, Michael Ashton
Antimicrobial agents and chemotherapy - 2002-01-01 -
Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum
malaria.
Ulrika S H Svensson, Hassan Alin, Mats O Karlsson, Yngve Bergqvist, Michael Ashton
European journal of clinical pharmacology - 2002-01-01 -
Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as
chemoprophylaxis.
Mita M Thapar, Michael Ashton, Niklas Lindegårdh, Yngve Bergqvist, Sabina Nivelius, Inger Johansson, Anders Björkman
European journal of clinical pharmacology - 2002-01-01 -
In vitro evidence for auto-induction of artemisinin metabolism in the
rat.
S Gupta, U S Svensson, Michael Ashton
European journal of drug metabolism and pharmacokinetics - 2001-01-01 -
Multiple dose study of interactions between artesunate and artemisinin in healthy
volunteers.
S Q Zhang, T N Hai, K F Ilett, D X Huong, T M Davis, Michael Ashton
British journal of clinical pharmacology - 2001-01-01