Doctoral StudentDepartment of Chemistry & Molecular
About Johanna Hörberg
I have a bachelor's and master's degree in organic and pharmaceutical chemistry. Now I'm doing my PhD studies in the group of computational chemistry and theoretical biochemistry, where I also did my master's thesis. I am primarily interested in understanding mechanisms for biological processes.
Supervisor: Dr. Anna Reymer and Prof. Leif Eriksson.
My PhD project focus on deriving mechanistic aspects for the regulation of DNA transcription at a molecular level by means of calculation methods (mainly molecular dynamic simulations). Transcription is regulated by transcription factors – a class of proteins that recognize and bind with high specificity short DNA sequences (so-called response elements) to initiate transcription of a gene. In our group, we try to understand how sequence-specific dynamics of DNA can regulate specific recognition of transcription factors and how protein-DNA dynamics can be linked to gene expression levels.
Sequence-specific dynamics of DNA response elements and their flanking sites regulate the recognition by AP-1 transcription
Specifically bound BZIP transcription factors modulate DNA supercoiling
New insights on human IRE1 tetramer structures based on molecular
Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to
M. Maurel, J. Obacz, T. Avril, Y. P. Ding, O. Papadodima, X. Treton, F. Daniel, E. Pilalis, Johanna Hörberg, W. Y. Hou, M. C. Beauchamp, J. Tourneur-Marsille, D. Cazals-Hatem, L. Sommerova, A. Samali, J. Tavernier, R. Hrstka, A. Dupont, D. Fessart, F. Delom, M. E. Fernandez-Zapico, G. Jansen, Leif A Eriksson, D. Y. Thomas, L. Jerome-Majewska, T. Hupp, A. Chatziioannou, E. Chevet, E. Ogier-Denis
EMBO Molecular Medicine - 2019-01-01
A sequence environment modulates the impact of methylation on the torsional rigidity of
QM/MM Studies of Dph5-A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of
Visible-Light-Mediated Photocatalytic Difunctionalization of Olefins by Radical Acylarylation and Tandem Acylation/Semipinacol