Frida Gorreja
About Frida Gorreja
Macrophages are predominant innate immue cells that can be found throughout our bodies, including in the human gastrointestinal tract. Inflammatory and tissue resident macrophages contribute to the pathogenesis of Inflammatory Bowel Diseases such as Crohn´s Disease. Once microbiota or pathogenic bacteria passes through the damaged intestinal barrier and activates macrophages they release pro-inflammatory and anti-inflammatory proteins/cytokines such as interleukin-1 beta (IL-1β), IL-10, tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β). Such homeostatic balance or pro-inflammatory and anti-inflammatory proteins, and the involvement of specific macrophage subtypes producing them, is imparied in Crohn´s Disease.
My research focuses in studying the macrophage phenotype and funtion in Crohn´s Disease with regards to microbiota involvement, disease location and disease subtypes. More information on my teams work can be found here https://www.gu.se/forskning/lena-ohman
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Isobaric labeling-based quantitative proteomics of FACS-purified immune cells and epithelial cells from the intestine of Crohn's disease patients reveals proteome changes of potential importance in disease
pathogenesis.
Johannes Alfredsson, Ivo Fabrik, Frida Gorreja, Charles Caër, Carina Sihlbom, Mattias Block, Lars Börjesson, Elinor Bexe-Lindskog, Mary Jo Wick
Proteomics - 2023 -
Systematic Review of Human and Animal Evidence on the Role of Buckwheat Consumption on Gastrointestinal
Health
Ezra Valido, Jivko Stoyanov, Frida Gorreja, Stevan Stojic, Christa Niehot, Jessica Kiefte-de Jong, Erand Llanaj, Taunt Muka, Marija Glisic
Nutrients - 2022 -
MEFV and NLRP3 Inflammasome Expression Is Attributed to Immature Macrophages and Correlates with Serum Inflammatory Proteins in Crohn ' s Disease
Patients
Frida Gorreja, Charles Caër, Stephen T.A Rush, Sophia K. Forsskål, Anetta Härtlova, Maria K Magnusson, Elinor Bexe-Lindskog, Lars Börjesson, Mattias Block, Mary Jo Wick
Inflammation - 2022 -
The potential role of adherence factors in probiotic function in the gastrointestinal tract of adults and pediatrics: a narrative review of experimental and human
studies.
Frida Gorreja, W Allan Walker
Gut microbes - 2022 -
TREM-1+ Macrophages Define a Pathogenic Cell Subset in the Intestine of Crohn's Disease
Patients
Charles Caër, Frida Gorreja, Sophia Forsskåhl, Siggeir Brynjolfsson, Louis Szeponik, Maria K Magnusson, Lars G. Börjesson, Mattias Block, Elinor Bexe-Lindskog, Mary Jo Wick
Journal of Crohn's & colitis - 2021 -
Gene expression changes as predictors of the immune-modulatory effects of probiotics: Towards a better understanding of strain-disease specific
interactions
Frida Gorreja
NFS Journal - 2019 -
The developmentally regulated fetal enterocyte gene, ZP4, mediates anti-inflammation by the symbiotic bacterial surface factor polysaccharide A on Bacteroides
fragilis
Frida Gorreja, S. T. A. Rush, D. L. Kasper, D. Meng, W. A. Walker
American Journal of Physiology-Gastrointestinal and Liver Physiology - 2019 -
Alternatives to animal testing in basic and preclinical research of atopic
dermatitis
Anna Löwa, Marijana Jevtić, Frida Gorreja, Sarah Hedtrich
Experimental Dermatology - 2018 -
A survey on patients medication reconciliation process in an oncological
hospital
Frida Gorreja, Vera Damuzzo, Umberto Gallo, Alberto Russi, Francesco Lo Re, Susanna Ciampalini, Lucia Guidotti, Marta Serena, Angelo Claudio Palozzo
Recenti Progressi in Medicina - 2017 -
Improving the management of high cost anticancer drugs in a health care
system
Alberto Russi, Vera Damuzzo, Marta Serena, Frida Gorreja, Angelo Palozzo
Global & Regional Health Technology Assessment - 2016