ResearcherDepartment of Rheumatology a Inflammation
About Ola Grimsholm
Short background: I defended my PhD Thesis in 2008 at Umeå University with Prof. Sture Forsgren as main supervisor and Prof. Solbritt Rantapää-Dahlqvist as co-supervisor. My Thesis described the peripheral nervous system in the inflamed joint during rheumatoid arthritis and in a mouse model therof. I did my first Post doc with Prof. Lill Mårtensson-Bopp at University of Gothenburg and that is where my interest on B cells started. Thereafter I decided to move to research on human memory B cells and I did a second Post doc in the laboratory of Dr. Rita Carsetti in Rome, Italy.
Main research focus: We focus mainly on human memory B cells in health and disease.We are running projects on primary antibody deficiencies and chronic lymphocytic leukemia. We are now about to start a project in the field of rheumatology as well on the role of memory B cells in Systemic sclerosis.
Join us! We are presently looking for Master Thesis students and a Post doc who wants to join the my lab. Please contact me for more information.
Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in
Alessandro Camponeschi, Natalija Gerasimcik, Ying Wang, Timothy Fredriksson, Dongfeng Chen, Chiara Farroni, Katrin Thorarinsdottir, Louise Sjökvist Ottsjö, Alaitz Aranburu, Susanna Cardell, Rita Carsetti, Inger Gjertsson, Inga-Lill Mårtensson, Ola Grimsholm
Frontiers in immunology - 2019-01-01
Dysregulated miR-155 and miR-125b are related to impaired B-cell responses in down
C. Farroni, E. Marasco, V. Marcellini, E. Giorda, D. Valentini, S. Petrini, V. D'Oria, M. Pezzullo, S. Cascioli, M. Scarsella, A. G. Ugazio, G. C. De Vincentiis, Ola Grimsholm, R. Carsetti
Frontiers in Immunology - 2018-01-01
Long-lived plasma cells in mice and
Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected
B-cell activation with CD40L or CpG measures the function of B-cell subsets and identifies specific defects in immunodeficient
E. Marasco, C. Farroni, S. Cascioli, V. Marcellini, M. Scarsella, E. Giorda, E. Piano Mortari, L. Leonardi, A. Scarselli, D. Valentini, C. Cancrini, M. Duse, Ola Grimsholm, R. Carsetti
Eur J Immunol - 2017-01-01
CD21-/low B cells in human blood are memory
Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B
Ola Grimsholm, Weicheng Ren, Angelina I Bernardi, Hai-Xia Chen, Giljun Park, Alessandro Camponeschi, Dongfeng Chen, Berglind Bergmann, Nina Höök, Sofia E M Andersson, Anneli Strömberg, Inger Gjertsson, Susanna Cardell, Ulf Yrlid, A. De Riva, Inga-Lill Mårtensson
Nature Communications - 2015-01-01
Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B
Memory B Cells in Mouse
Uncoupling of Natural IgE Production and CD23 Surface Expression
The pre-B cell receptor