Publications
Here are all peer-reviewed publications by CARe
2020
Dimovska Nilsson K, Grandén J, Farewell A, Fletcher JS. (2020). Interrogation of chemical changes on, and through, the bacterial envelope of Escherichia coli FabF mutant using time‐of‐flight secondary ion mass spectrometry. Surface and Interface Analysis. https://doi.org/10.1002/sia.6905
Nijsingh N, Larsson DGJ, de Fine Licht K, Munthe C. (2020). Justifying Antibiotic Resistance Interventions: Uncertainty, Precaution and Ethics. Chapter 22, pp 357-375 In: E. Jamrozik, M. Selgelid (eds.), Ethics and Drug Resistance: Collective Responsibility for Global Public Health, Public Health Ethics Analysis 5.Springer, Cham, https://doi.org/10.1007/978-3-030-27874-8_22
Berglund, F., Böhm, M., Martinsson, A., Ebmeyer, S., Österlund, T., Johnning, A., Larsson, DGJ., Kristiansson, E. (2020). Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes. Microbial Genomics. Accepted for publication.
Nieuwenhuijse, D.F., Oude Munnink, B.B., Phan, M.V.T….Larsson DGJ….et al (ca 100 co-authors) (2020). Setting a baseline for global urban virome surveillance in sewage. Scientific Reports 10, 13748. https://doi.org/10.1038/s41598-020-69869-0
Kraupner N, Ebmeyer S, Hutinel M, Fick J, Flach C-F, Larsson DGJ. (2020). Selective concentrations for trimethoprim resistance in aquatic environments. Environment international. https://doi.org/10.1016/j.envint.2020.106083.
Malmqvist E & Munthe C. (2020). What High-Income States Should Do to Address Industrial Antibiotic Pollution. Public Health Ethics. https://academic.oup.com/phe/advance-article/doi/10.1093/phe/phaa020/5900376
Buongermino Pereira M, Österlund T, Eriksson KM, Backhaus T, Axelson-Fisk M and Kristiansson E. (2020). A comprehensive survey of integron-associated genes present in metagenomes. BMC Genomics 21:495. http://dx.doi.org/10.1186/s12864-020-06830-5
Jaén-Luchoro D, Gonzales-Siles L, Karlsson R, Svensson-Stadler L, Molin K, Cardew S, Jensie-Markopolous S,Ohlén M, Inganäs E, Skovbjerg S, Tindalle BJ, Moore ERB. (2020). Corynebacterium sanguinis sp. nov., a clinical and environmental associated corynebacterium. Systematic and Applied Microbiology, 43. https://doi.org/10.1016/j.syapm.2019.126039
Müller V, Nyblom M, Johnning A, Wrande M, Dvirnas A, Sriram KK, Giske CG, Ambjörnsson T, Sandegren L, Kristiansson E, Westerlund F. (2020). Cultivation-Free Typing of Bacteria Using Optical DNA Mapping. ACS Infec Dis, 6. http://dx.doi.org/10.1021/acsinfecdis.9b00464
Berglund F, Johnning A, Larsson, DGJ Kristiansson, E. (2020). An updated phylogeny of the metallo-beta-lactamases. Journal of Antimicrobial Chemotherapy. Accepted for publication.
Mamedov I, Naghiyev F, Maharramov A, Uwangue O, Farewell A, Sunnerhagen P, Erdelyi M. (2020). Antibacterial activity of 2-amino-3-cyanopyridine derivatives. Mendeleev Commun. 30. https://doi.org/10.1016/j.mencom.2020.07.031
Razavi M, Flach C-F, Kristiansson E, Larsson DGJ. (2020). The association between insertion sequences and antibiotic resistance genes. mSphere. DOI: 10.1128/mSphere.00418-20.
Zhang T, Fukuda K, Topp E, Zhu Y-G, Smalla K, Tiedje JM, Larsson DGJ. (2020). Editorial: The Environmental Dimension of Antibiotic Resistance, FEMS Microbiology Ecology, 96 (8): fiaa130. https://doi.org/10.1093/femsec/fiaa130.
Leiros H-K S, Thomassen A M, Samuelsen Ø , Flach C-F, Kotsakis S D, Larsson DGJ. 2020. Structural insight to the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10. FEBS Open Bio. DOI: https://doi.org/10.1002/2211-5463.12935.
Salvà-Serra F, Jaén-Luchoro D, E. Jakobsson H, Gonzales-Siles L, Karlsson R, Busquets A, Gomila M, Bennasar-Figueras A, Russell JE, Abbas Fazal M, Alexander S, Moore ERB. (2020). Scientific Reports. http://dx.doi.org/10.1038/s41598-020-68249-y
Zaborowska M, Taulé Flores C, Vazirisani F, Shah FA, Thomsen P, Trobos M. (2020). Extracellular Vesicles Influence the Growth and Adhesion of Staphylococcus epidermidis Under Antimicrobial Selective Pressure. http://dx.doi.org/10.3389/fmicb.2020.01132
Kvint K, Palm M, Farewell A. (2020). Teaching about Antibiotic Resistance to a Broad Audience: A multidisciplinary approach. FEMS Microbiology Letters. https://doi.org/10.1093/femsle/fnaa111
Fröhlich C, Sörum V, Huber S, Samuelsen Ö, Berglund F, Kristiansson E, Kotsakis S, Marathe NP, Larsson DGJ, Leiros H-K S. (2020). Structural and biochemical characterization of the environmental metallo-β-lactamases MYO-1, ECV-1 and SHD-1. J Antimicrob Chemother. DOI: 10.1093/jac/dkaa175
Nijsingh N, Christian Munthe C, Lindblom A, Christina Åhrén. (2020). Screening for multi-drug-resistant Gram-negative bacteria: what is effective and justifiable? Monash Bioethics Review. https://doi.org/10.1007/s40592-020-00113-1
Davis M, Lyall B, Whittaker A, Lindgren M, Djerf-Pierre M, Flowers P. (2020). A year in the public life of superbugs: News media on antimicrobial resistance and implications for health communications. Social Science & Medicine, 256. https://doi.org/10.1016/j.socscimed.2020.113032
Tamire M, Addissie A, Kumie A, Husmark E, Skovbjerg S, Andersson R, Lärstad M. (2020). Respiratory Symptoms and Lung Function among Ethiopian Women in Relation to Household Fuel Use. Int J Env Res Pub Health. https://www.mdpi.com/1660-4601/17/1/41/pdf
Böhm M-E, Razavi M, Flach C-F, Larsson DGJ. (2020). A novel, integron-regulated class C β-lactamase. Antibiotics. DOI: https://doi.org/10.3390/antibiotics9030123.
Eckert EM, Di Cesare A, Fontaneto D, Berendonk TU, Bürgmann H, Cytryn E, Fatta-Kassinos D, Franzetti A, Larsson DGJ, Manaia CM, Pruden A, Singer AC, Udikovic-Kolic N, Corno G. (2020). Every fifth published metagenome is not available to science. PloS Biology. DOI: https://doi.org/10.1371/journal.pbio.3000698.
Huijbers PMSC, Larsson DGJ, Flach C-F. (2020). Surveillance of antibiotic resistant Escherichia coli in human populations through urban wastewater in ten European countries. Environmental Pollution. DOI: 10.1016/j.envpol.2020.114200 .
Gunnarsson RK & Manchal N. (2020). Group C beta hemolytic Streptococci as a potential pathogen in patients presenting with an uncomplicated acute sore throat – a systematic literature review and meta-analysis. Scandinavian Journal of Primary Health Care. https://doi.org/10.1080/02813432.2020.1753374
Böhm M-E, Razavi M, Marathe NP, Flach C-F, Larsson DGJ. (2020). Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities. Microbiome. https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00814-z.
Laxminarayan R, Van Boeckel T, Frost I, Kariuki S, Khan E, Limmathurotsakul D, Larsson DGJ, Levy-Hara G, Mendelson M, Outterson K, Peacock S, Zhu Y-G. (2020). The Lancet Infectious Diseases Commission on antimicrobial resistance: six years later. Lancet Infect Dis. DOI: https://doi.org/10.1016/S1473-3099(20)30003-7
Karlsson R, Thorsell A, Gomila M, Salvà-Serra F, Jakobsson HE, Gonzales-Siles L, Jaén-Luchoro D, Skovbjerg S, Fuchs J, Karlsson A, Boulund F, Johnning A, Kristiansson E, Moore ERB. (2020). Discovery of Species-unique Peptide Biomarkers of Bacterial Pathogens by Tandem Mass Spectrometry-based Proteotyping. Mol & Cell Proteomics, 19. http://dx.doi.org/10.1074/mcp.RA119.001667
Bengtsson-Palme J, Heß S. (2020). Strategies to reduce or eliminate resistant pathogens in the environment. In: Capelo Martinez JL, Igrejas G (Eds.) Antibiotic Drug Resistance, 637–673. Wiley, NJ, USA. doi: 10.1002/9781119282549.ch24
Maeda G, van der Wal J, Gupta AK, Munissi JJE, Orthaber A, Sunnerhagen P, Nyandoro SS, Máté Erdélyi M. (2020). Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa. J Nat Prod, 83. http://dx.doi.org/10.1021/acs.jnatprod.9b00363
Rutgersson C, Ebmeyer S, Lassen SB, Karkman A, Fick J, Kristiansson K, Brandt KK, Flach C-F, Larsson DGJ. (2019). Long-term application of Swedish sewage sludge on farmland does not cause clear changes in the soil bacterial resistome. Environ Int. 137:105339. doi: 10.1016/j.envint.2019.105339
2019
Skoog Ståhlgren G, Tyrstrup M, Edlund C, Giske CG, Mölstad S, Norman C, Rystedt K, Sundvall PD, Hedin K. (2019). Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study. BMJ. 2019 Oct 4;367:l5337. doi: 10.1136/bmj.l5337.
Emgård M, Msuya SE, Nyombi BM, Mosha D, Gonzales-Siles L, Nordén R, Geravandi S, Mosha V, Blomqvist J, Franzén S, Sahlgren F, Andersson R, Skovbjerg S. (2019). Carriage of penicillin non-susceptible pneumococci among children in northern Tanzania in the 13-valent pneumococcal vaccine era. Int J Infect Dis. Jan 24;81:156-166
Marathe NP, Salvà-Serra F, Karlsson R, Larsson DGJ, Moore ERB, Svensson-Stadler L, Jakobsson HE.(2019). Scandinavium goeteborgense gen. nov., sp. nov., a New Member of the Family Enterobacteriaceae Isolated From a Wound Infection, Carries a Novel Quinolone Resistance Gene Variant. Front Microbiol. 2019 Nov 5;10:2511. https://doi.org/10.3389/fmicb.2019.02511
Carlsson F, Jacobssonb G, Jagers S, Lampi E, Robertson F, Rönnerstrand B.(2019). Who is willing to stay sick for the collective? – Individual characteristics, experience, and trust. SSM Popul Health. 9:100499. https://doi.org/10.1016/j.ssmph.2019.100499
Heß S, Kneis D, Österlund T, Li B, Kristiansson E, Berendonk TU. (2019). Sewage from Airplanes Exhibits High Abundance and Diversity of Antibiotic Resistance Genes. Environ Sci Technol. Nov 12. doi: 10.1021/acs.est.9b03236.
Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila. Int J Antimicrob Agents. 54(6):798-802. https://doi.org/10.1016/j.ijantimicag.2019.09.017
Munthe C, Nijsingh N, de Fine Lich K, Larsson DGJ. (2019). The Ethics of Antibiotic Resistance: Towards an Agenda for Feasible and Justified Global Health Policy. Bioethics. 33(7):731-733. https://doi.org/10.1111/bioe.12655
Nilsson KD, Palm M, Hood J, Sheriff J, Farewell A, Fletcher JS. (2019). Chemical Changes On, and Through, The Bacterial Envelope in Escherichia coli Mutants Exhibiting Impaired Plasmid Transfer Identified Using Time-of-Flight Secondary Ion Mass Spectrometry. Anal. Chem.2019. https://doi-org.ezproxy.ub.gu.se/10.1021/acs.analchem.9b02533
Bengtsson-Palme J, Milakovic M, Švecová H, Ganjto M, Jonsson V, Grabic R, Udiković Kolić N. (2019). Industrial wastewater treatment plant enriches resistance genes and alter the structure of microbial communities. Water Research, 162, 437-445. doi: 10.1016/j.watres.2019.06.073
Monjas L, Fodran P, Kollback J, Cassani C, Olsson T, Genheden M, Larsson DGJ, Wallentin C-J. (2019). Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents. Beilstein J. Org. Chem. 2019 15:1468–1474. doi:10.3762/bjoc.15.147
Davies JS, Coombes D, Horne CR, Pearce FG, Friemann R, North RA, Dobson RCJ. (2019). N-Acetylglucosamine-6-phosphate deacetylase and glucosamine-6-phosphate deacetylase from Staphylococcus aureus: Function and solution structure studies, FEBS Lett, doi: 10.1002/1873-3468.13289
Ruppé E, Bengtsson-Palme J, Charretier Y, Schrenzel J. (2019). How next-generation sequencing can address the antimicrobial resistance challenge. AMR Control, 2019-20, 60-65. Link to paper.
Marathe NP, Berglund F, Razavi M, Pal C, Dröge J, Samant S, Kristiansson E, Larsson DGJ. (2019). Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes. Microbiome. 2019 7:97. https://doi.org/10.1186/s40168-019-0710-x
Huijbers PMC, Flach C-F, Larsson DGJ. (2019). A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance. Environ Int. https://doi.org/10.1016/j.envint.2019.05.074
Ljungström L, Andersson R, Jacobsson G. (2019). Incidences of Community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden - a prospective population-based study. PLOS One Published December 5, https://doi.org/10.1371/journal.pone.0225700
Bengtsson-Palme J. (2019). Assessment and management of risks associated with antibiotic resistance in the environment. In: Roig B, Weiss K, Thoreau V (Eds.) Management of Emerging Public Health Issues and Risks: Multidisciplinary Approaches to the Changing Environment, 243–263. Elsevier, UK. doi: 10.1016/B978-0-12-813290-6.00010-X
Rönnerstrand, B. (2019). Dystopiernas kamp: svenskarnas syn på klimatförändringar och antibiotikaresistens i jämförelse i Ulrika Andersson, Björn Rönnerstrand, Patrik Öhberg & Annika Bergström (red) Storm och stiltje. 1 Göteborgs universitet: SOM-institutet.
Hendriksen RS, Munk P, Niage P, van Bunnik B,…., Larsson DGJ,….(ca 100 co-authors). (2019). Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nature communications 10, 1124. https://doi.org/10.1038/s41467-019-08853-3
Berglund F, Österlund T, Boulund F, Marathe NP, Larsson DGJ, Kristiansson E. (2019). Identification and reconstruction of novel antibiotic resistance genes from metagenomes. Microbiome 2019 7:52 https://doi.org/10.1186/s40168-019-0670-1
Pippione AC, Sainas S, Goyal P, Fritzson I, Cassiano GC, Giraudo A, Giorgis M, Tavella TA, Bagnati R, Rolando B, Caing-Carlsson R, Costa FTM, Andrade CH, Al-Karadaghi S, Boschi D, Friemann R, Lolli ML. (2019). Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: synthesis, biological evaluation and X-ray structural studies, Eur J Med Chem, 163:266-280. https://doi.org/10.1016/j.ejmech.2018.11.044
Durán RE, Méndez V, Rodríguez-Castro L, Barra-Sanhueza B, Salvá-Serra F, Moore ERB, Castro-Nallar E, Seeger M. (2019). Genomic and Physiological Traits of the Marine Bacterium Alcaligenes aquatilis QD168 Isolated From Quintero Bay, Central Chile, Reveal a Robust Adaptive Response to Environmental Stressors. Front. Microbiol. https://doi.org/10.3389/fmicb.2019.00528
Djerf-Pierre M, Lindgren, M, and Budinski, M A. (2019). The role of journalism on YouTube: Audience engagement with ’Superbug’ reporting. Media and Communication 7(1): 235-247. Doi: 10.17645/mac.v7i1.1758
Guzman-Otazo J, Gonzales-Siles L, Poma V, Bengtsson-Palme J, Thorell K, Flach CF, Iñiguez V, Sjöling Å. (2019). Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia. PLoS ONE. https://doi.org/10.1371/journal.pone.0210735
Munthe C, Nijsingh N, de Fine Licht K, Larsson DGJ. (2019). Health-related research ethics and social value: antibiotic resistance intervention research and pragmatic risks. Bioethics, 2019;33:335–342. DOI: doi.org/10.1111/bioe.12580
Karkman A., Pärnänen K. and DGJ Larsson. (2019). Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments. Nature Communications. 80:10. DOI: https://www.nature.com/articles/s41467-018-07992-3
Ebmeyer S, Kristiansson E, Larsson DGJ. (2019). PER extended-spectrum beta-lactamases originate from Pararheinheimera spp. J Antimicrobial Agents. 53:158 https://doi.org/10.1016/j.ijantimicag.2018.10.019.
2018
Karlsson R, Gonzales-Siles L, Gomila M, Busquets A, Salvà-Serra F, Jaén-Luchoro D, Jakobsson E H, Karlsson A, Boulund F, Kristiansson E, Moore ERB. (2018). Proteotyping bacteria: Characterization, differentiation and identification of pneumococcus and other species within the Mitis Group of the genus Streptococcus by tandem mass spectrometry proteomics. PLoS One. https://doi.org/10.1371/journal.pone.0208804
Aga D, Davies J, Gandra S, Kasprzyk B, DGJ Larsson, McLain J, Singer A, Snape J, Slijkhuis H, Sweetman A, Voulvoulis N. (2018). Antimicrobial manufacturing waste. Pages 30-45. In: Initiatives for Addressing Antimicrobial Resistance in the Environment: Current Situation and Challenges. https://wellcome.ac.uk/sites/default/files/antimicrobial-resistance-environment-report.pdf
Jonsson V, Österlund T, Nerman O, Kristiansson E. (2018). Modelling of zero-inflation improves inference of metagenomic gene count data. Stat Methods Med Res. 2018. doi: https://doi.org/10.1177/0962280218811354
Johnning A, Karami N, Tång Hallbäck E, Müller V, Nyberg L, Buongermino Pereira M, Stewart C, Ambjörnsson T, Westerlund F, Adlerberth I, Kristiansson E. (2018). The resistomes of six carbapenem-resistant pathogens – a critical genotype–phenotype analysis. Microbial Genomics. doi: 10.1099/mgen.0.000233
Munthe, C, El-Alti, L, Hartvigsson, T, Nijsingh, N (2018). Disputing with patients in person-centered care: Ethical aspects in standard care, pediatrics, psychiatry, and public health. Journal of Argumentation in Context 7(2): 233-246. DOI: https://doi.org/10.1075/jaic.18022.mun
Kotsakis S, Flach CF, Razavi M, Larsson DGJ. (2018). Characterization of the first OXA-10 natural variant with increased carbapenemase activity. Antimicrobial Agents and Chemotherapy. https://aac.asm.org/content/early/2018/10/31/AAC.01817-18.long
Karp J, Edman-Wallér J, Toepfer M, Lundqvist A, G Jacobsson. (2018). Clostridioides difficile incidence related to in-hospital cephalosporin use: a tale of two highly comparable hospitals. J Antimicrob Chemother. https://doi.org/10.1093/jac/dky408
Graf FE, Palm M, Warringer J, Farewell A. (2018). Inhibiting conjugation as a tool in the fight against antibiotic resistance. Drug development research. https://doi.org/10.1002/ddr.21457
Pärnänen K, Karkman A, Hultman J, Lyra C, Bengtsson-Palme J, Larsson DGJ, Rautava S, Salminen S, Kumar H, Satokari R, Isolauri E, Virta M. (2018). Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements. Nature Communications. https://doi.org/10.1038/s41467-018-06393-w
Flach CF, Genheden M, Fick J, DGJ Larsson. (2018). A comprehensive screening of E. coli isolates from Scandinavia’s largest sewage treatment plant indicates no selection for antibiotic resistance. Environmental Science & Technology. https://pubs.acs.org/doi/10.1021/acs.est.8b03354
Bengtsson-Palme, J. (2018). The diversity of uncharacterized antibiotic resistance genes can be predicted from known gene variants—but not always. Microbiome. 6:125. microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0508-2 https://doi.org/10.1186/s40168-018-0508-2
Birindwa AM, Emgård M, Nordén R, Samuelsson E, Geravandi S, Gonzales-Siles L, Muhigirwa B, Kashosi T, Munguakonkwa E, Manegabe JT, Cibicabene D, Morisho L, Mwambanyi B, Mirindi J, Kabeza N, Lindh M, Andersson R, Skovbjerg S. (2018). High rate of antibiotic resistance among pneumococci carried by healthy children in the eastern part of the Democratic Republic of the Congo. BMC Pediatrics 2018; 18:361 https://rdcu.be/bbLnV
Bahram M, Hildebrand F, Forslund SK, Anderson JL, Soudzilovskaia NA, Bodegom PM, Bengtsson-Palme J, Anslan S, Coelho LP, Harend H, Huerta-Cepas J, Medema MH, Maltz MR, Mundra S, Olsson PA, Pent M, Põlme S, Sunagawa S, Ryberg M, Tedersoo L, Bork P. (2018). Structure and function of the global topsoil microbiome. Nature. DOI: 10.1038/s41586-018-0386-6
Walujkar SA, Kumbhare SV, Marathe NP, Patangia DV, Lawate PS, Bharadwaj RS, Shouche YS. (2018). Molecular profiling of mucosal tissue associated microbiota in patients manifesting acute exacerbations and remission stage of ulcerative colitis. World J Microbiol Biotechnol. 34:76. DOI: 10.1007/s11274-018-2449-0
Lindblom A, Sriram KK, Müller V, Öz R, Sandström H, Åhrén C, Westerlund F, Karami N. (2018). Interspecies plasmid migration appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Diagn Microb Inf Dis. https://doi.org/10.1016/j.diagmicrobio.2018.10.014
Thomsen H, Graf FE, Farewell A, Ericson MB. (2018). Exploring photoinactivation of microbial biofilms using laser scanning microscopy and confined 2-photon excitation. J Biophotonics. 2018 Oct;11(10):e201800018. https://doi.org/10.1002/jbio.201800018
Kapla M, Munthe C, Rönnerstrand B, Svensson J, Vedinelli C. (2018). Antibiotikaresistens – hoten och vägen framåt. PODD, Ord & Bild, October 22, 2018. Online: http://www.tidskriftenordobild.se/ordoblogg/category/podd-om-antibiotikaresistens
Lindgren Å, Karami N, Karlsson R, Åhrén C, Welker M, Moore ERB, Stadler LS. (2018). Development of a rapid MALDI-TOF MS based epidemiological screening method using MRSA as a model organism. Eur J Clin Microbiol Infect Dis. DOI: 10.1007/s10096-017-3101-x
Moradigaravand D, Palm M, Farewell A, Mustonen V, Warringer J, Parts L. (2018). Precise prediction of antibiotic resistance in Escherichia coli from full genome sequences. CSH bioRxi doi: https://doi.org/10.1101/338194
Munthe C, Nijsingh N. (2018). Cutting red tape to manage drastic public health threats: Should antimicrobial drug innovation be expedited? In review. (Preprint online: https://www.researchgate.net/publication/325694548_Cutting_red_tape_to_manage_drastic_public_health_threats_Should_antimicrobial_drug_innovation_be_expedited )
Larsson DGJ, Andremont A, Bengtsson-Palme J, Koefoed Brandt K, de Roda Husman AM, Fagerstedt P, Fick J, Flach CF, Gaze WH, Kuroda M, Kvint K, Laxminarayan R, Manaia CM, Nielsen KM, Plant L, Ploy MC, Segovia C, Simonet P, Smalla K, Snape J, Topp E, van Hengel A, Verner-Jeffreys DW, Virta MPJ, Wellington EM, Wernersson AS. (2018). Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance. Environ Int. 117:132-138. https://doi.org/10.1016/j.envint.2018.04.041
Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. (2018). Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nat Commun. 1;9(1):1753. doi: 10.1038/s41467-018-04045-7.
Kraupner N, Ebmeyer S, Bengtsson-Palme J, Fick J, Kristiansson E, Flach C-F, Larsson DGJ. (2018). Selective concentration for ciprofloxacin resistance in Escherichia coli grown in complex aquatic bacterial biofilms. Environ Int. 116:255-268. https://doi.org/10.1016/j.envint.2018.04.029
Lindblom A, Karami N, Magnusson T, Åhrén C. (2018). Subsequent infection with extended-spectrum β-lactamase-producing Enterobacteriaceae in patients with prior infection or fecal colonization. Eur J Clin Microbiol Infect Dis. https://doi.org/10.1007/s10096-018-3275-x
Pereira MB, Wallroth M, Jonsson V, Kristiansson E. (2018). Comparison of normalization methods for the analysis of metagenomic gene abundance data, BMC Genomics 19(274). https://doi.org/10.1186/s12864-018-4637-6
Munthe C, El-Alti L, Hartvigsson T, Nijsingh N (2018). Disputing with Patients in Person-Centered Care: Ethical Aspects in Standard Care, Pediatrics, Psychiatry, and Public Health. Journal of Argumentation in Context, Accepted and in press
Topp E, Larsson DGJ, Miller DN, Van den Eede C, Virta MPJ. (2018). Antimicrobial resistance and the environment: assessment of advances, gaps and recommendations for agriculture, aquaculture and pharmaceutical manufacturing. FEMS Microbiol Ecol. 2018 Mar 1;94(3). doi: 10.1093/femsec/fix185
Marathe NP, Janzon A, Kotsakis SD, Flach C-F, Razavi M, Berglund F, Kristiansson E, Larsson DGJ. (2018). Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste. Environ Int. 112:279-286. http://doi.org/10.1016/j.envint.2017.12.036.
Thomsen H, James J, Farewell A, M.B. Ericson, (2018), Spatially confined photoinactivation of bacteria: towards novel tools for detailed mechanistic studies. SPIE proc 10498. DOI: 10.1117/12.2290718
Hanna Alalam, Fabrice E. Graf, Martin Palm, Marie Abadikhah, Martin Zackrisson, Matilda Mattsson, Chris Hadjineophytou, Linnéa Persson, Simon Stenberg, Payam Ghiaci, Per Sunnerhagen, Jonas Warringer, Anne Farewell. (2018). Conjugation factors controlling F-plasmid antibiotic resistance transmission. CSH bioRxi doi: https://doi.org/10.1101/271254
Robertson F, Jagers S, Rönnerstrand B. (2018). Managing Sustainable Use of Antibiotics—The Role of Trust. Sustainability. doi:10.3390/su10010143
Nijsingh N. (2018) "Antibiotica-resistentie: een complexe catastrofe”, Podium voor Bio-Ethiek, 24(2): 20-22.
Larsson DGJ. (2018). Risks of using the natural defense of commensal bacteria as antibiotics call for research and regulation. Int J Antimicrob Agents. https://doi.org/10.1016/j.ijantimicag.2017.12.018
Bengtsson-Palme J, Gunnarsson L, Larsson DGJ. (2018). Can branding and price of pharmaceuticals guide informed choices towards improved pollution control during manufacturing? J Clean Prod. 171:137 https://doi.org/10.1016/j.jclepro.2017.09.247
Bengtsson-Palme J, Larsson DGJ. (2018). Protection goals must guide risk assessment for antibiotics. Environment international. In press. http://dx.doi.org/10.1016/j.envint.2017.10.019
Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2018). Environmental factors influencing the development and spread of antibiotic resistance. FEMS Micro Rev. 1;42. https://doi.org/10.1093/femsre/fux053
2017
Razavi M, Marathe NP, Gillings MR, Flach CF, Kristiansson E, Larsson DGJ. (2017). Discovery of the fourth mobile sulfonamide resistance gene. Microbiome. 5:160. https://doi.org/10.1186/s40168-017-0379-y
Mölstad S, Löfmark S, Carlin K, Erntell M, Aspevall O, Blad L, Hanberger H, Hedin K, Hellman J, Norman C, Skoog G, Stålsby-Lundborg C, Tegmark Wisell K, Åhrén C, Cars O. (2017) Lessons learnt during 20 years of the Swedish strategic programme against antibiotic resistance. Bull World Health Organ. 2017:95(11):764-773. doi: 10.2471/BLT.16.184374
North RA, Horne CR, Davies JS, Remus DM, Muscroft-Taylor AC, Goyal P, Wahlgren WY, Ramaswamy S, Friemann R, Dobson RCJ. (2017). "Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes. Biophys Rev. Dec 8. doi: 10.1007/s12551-017-0343-x. [Epub ahead of print] Review.
Jutkina J, Marathe NP, Flach C-F, Larsson DGJ. (2017). Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Sci Total Environ. Nov 4;616-617:172-178. https://doi.org/10.1016/j.scitotenv.2017.10.312
Ljungström L, Pernestig A-K, Jacobsson G, Andersson R, Usener B, Tilevik D. (2017). Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis. PLoS ONE 12(7): e0181704. https://doi.org/10.1371/journal.pone.0181704
Berglund F, Nachiket MP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Larsson DGJ, Kristiansson E. (2017). Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome. 5:134. https://doi.org/10.1186/s40168-017-0353-8.
Lindgren Å, Karami N, Karlsson R, Åhrén C, Welker M, Moore ERB, Stadler LS. (2017). Development of a rapid MALDI-TOF MS based epidemiological screening method using MRSA as a model organism. Eur J Clin Microbiol Infect Dis. Sep 18. https://doi.org/10.1007/s10096-017-3101-x
Boulund F, Berglund F, Flach C-F, Bengtsson-Palme J, Marathe NP, Larsson DGJ, Kristiansson E. (2017). Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets. BMC Genomics 18:682
https://doi.org/10.1186/s12864-017-4064-0
Monika Djerf-Pierre och Adam Shehata. (2017) Medierna och människors oro för antibiotikaresistens. Larmar och gör sig till. Sid. 169-186. SOM-institutets böcker. ISBN 978-91-89673-39-7.
Nachiket P.Marathe, ChandanPal, Swapnil S.Gaikwad, ViktorJonsson, ErikKristiansson, and D.G. JoakimLarsson. (2017). Untreated urban waste contaminates Indian river sediments with resistance genes to last resort antibiotics. Water Res. Nov 1;124:388-397. https://doi.org/10.1016/j.watres.2017.07.060.
Bengtsson-Palme J., Larsson DGJ., Kristiansson E. (2017). Using metagenomics to investigate human and environmental resistomes. J Antimicrob Chemother. https://doi.org/10.1093/jac/dkx199
Alsterholm M, Strömbeck L, Ljung A, Karami N, Widjestam J, Gillstedt M, Åhren C and Faergemann J. (2017). Variation in Staphylococcus aureus Colonization in Relation to Disease Severity in Adults with Atopic Dermatitis during a Five-month Follow-up. Acta Derm Venereol. Jul 6;97(7):802-807. doi: 10.2340/00015555-2667.
Mark Davis, Andrea Whittaker, Mia Lindgren, Monika Djerf-Pierre, Lenore Manderson & Paul Flowers. (2017). Understanding media publics and the antimicrobial resistance crisis. Global Public Health. P ages 1-11 | Published online: 08 Jun 2017. http://dx.doi.org/10.1080/17441692.2017.1336248
Boulund F, Karlsson R, Gonzales-Siles L, Johnning A, Karami N, Al-Bayati O, Åhrén C, Moore ERB, Kristiansson E. (2017). Typing and Characterization of Bacteria Using Bottom-up Tandem Mass Spectrometry Proteomics. Mol Cell Proteomics. Jun;16(6):1052-1063. doi: 10.1074/mcp.M116.061721. Epub 2017 Apr 18.
Ljungström LR, Jacobsson G, Claesson BEB, Andersson R, Enroth H. (2017). Respiratory viral infections are underdiagnosed in patients with suspected sepsis. Eur J Clin Microbiol Infect Dis. May 17. doi: 10.1007/s10096-017-2990-z.
Jakobsson HE, Salvà-Serra F, Thorell K, Karlsson R, Gonzales-Silès L, Boulund F, Engstrand L, Kristiansson E, Moore ER. (2017). Draft Genome Sequences of Six Strains of Streptococcus pneumoniae from Serotypes 5, 6A, 6B, 18C, 19A, and 23F. Genome Announc. Apr 6;5(14). pii: e00125-17. doi: 10.1128/genomeA.00125-17.
J. Bengtsson-Palme. (2017). Antibiotic resistance in the food supply chain: Where can sequencing and metagenomics aid risk assessment? Curr Opin Food Sci. Volume 14, April , Pages 66–71. http://dx.doi.org/10.1016/j.cofs.2017.01.010.
Flach CF, Pal C, Svensson CJ, Kristiansson E, Östman M, Bengtsson-Palme J, Tysklind M, Larsson DGJ. (2017). Does antifouling paint select for antibiotic resistance? Science of the Total Environment. Volumes 590–591, 15 July , Pages 461–468. doi: 10.1016/j.scitotenv.2017.01.213.
Hao X*, Li X*, Pal C*, Hobman J, Rosen BP, Larsson DGJ, Saquib Q, Alwathnani HA, Zhu Y-G, Rensing C. (2017). Bacterial resistance to arsenic protects against protist killing. Biometals. Biometals. Volume 30, Issue 2, pp 307–311. doi: 10.1007/s10534-017-0003-4 (*-co-first authors).
Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL. (2017). Metal resistance and its association with antibiotic resistance. Advances in Microbial Physiology. Volume 70, Chapter 7, Pages 261-313. ISBN: 9780128123867.
Helldal L, Karami N, Welinder-Olsson C, Moore ER, Åhren C. (2017). Evaluation of MLVA for epidemiological typing and outbreak detection of ESBL-producing Escherichia coli in Sweden. BMC Microbiol. 2017 Jan 6;17(1):8. doi: 10.1186/s12866-016-0922-1. PMID:28061803
Rönnerstrand, B. och V. Lapurente. (2017). Corruption and use of antibiotics in regions of Europe. Health Policy. Mar;121(3):250-256. doi: 10.1016/j.healthpol.2016.12.010. Epub 2017, Jan 7.
2016
Ballard MS, Schønheyder HC, Knudsen JD, Lyytikäinen O, Dryden M, Kennedy KJ, Valiquette L, Pinholt M, Jacobsson G, Laupland KB; International Bacteremia Surveillance Collaborative. The changing epidemiology of group B streptococcus bloodstream infection: a multi-national population-based assessment. Infect Dis (Lond). 2016;48(5):386-91. doi: 10.3109/23744235.2015.1131330.
North RA, Watson AJ, Pearce FG, Muscroft-Taylor AC, Friemann R, Fairbanks AJ, Dobson RC. Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus. FEBS Lett. 2016 Dec;590(23):4414-4428. doi: 10.1002/1873-3468.12462.
Bengtsson-Palme J and Larsson DGJ. (2016) Time to limit antibiotic pollution. The medicine maker, April issue, pp 17-18. (opinion paper).
Bengtsson-Palme J, Larsson DGJ (2016). Why limit antibiotic pollution? The role of environmental selection in antibiotic resistance development. APUA Newsletter, 34(2), 6-9.
Bengtsson-Palme J, Hammarén R, Pal C, Östman M, Björlenius B, Flach C-F, Fick J, Kristiansson E, Tysklind M, Larsson DGJ. (2016). Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics. Science of the Total Environment. doi: 10.1016/j.scitotenv.2016.06.228.
De Roda Husman A-M, Larsson DGJ (2016). Risk assessment and risk management of antimicrobial resistance in the environment. AMR control 2016. Pages 104-107. Global Health Dynamics, UK.
Edman-Wallér J, Ljungström L, Jacobsson G, Andersson R, Werner M. Systemic symptoms predict presence or development of severe sepsis and septic shock. Infect Dis (Lond). 2016;48(3):209-14. doi: 10.3109/23744235.2015.1104719.
Gao C, Uzelac I, Gottfries J, Eriksson LA. Exploration of multiple Sortase A protein conformations in virtual screening. Sci Rep. 2016 Feb 5;6:20413. doi: 10.1038/srep20413.
Johnning A, Jakobsson H, Boulund F, Salvà Serra F, Moore ERB, Åhrén C, Karami N, Kristiansson E. Draft genome sequence of extended-spectrum β-lactamase-producing Escherichia coli, strain CCUG 62462, isolated from a urine sample" Genome Announc. 2016 Dec 15;4(6). pii: e01382-16. doi: 10.1128/genomeA.01382-16.
Jonsson V, Österlund T, Nerman O, Kristiansson E. Statistical evaluation of methods for identification of differentially abundant genes in comparative metagenomics. BMC Genomics. 2016 Jan 25;17:78. doi: 10.1186/s12864-016-2386-y.
Jonsson V, Österlund T, Nerman O, Kristiansson E. Variability in Metagenomic Count Data and Its Influence on the Identification of Differentially Abundant Genes. J Comput Biol. 2016 Nov 28.
Karami N, Wold AE, Adlerberth I. Antibiotic resistance is linked to carriage of papC and iutA virulence genes and phylogenetic group D background in commensal and uropathogenic Escherichia coli from infants and young children. Eur J Clin Microbiol Infect Dis. 2016 Dec 6.
Kwiecinski J, Peetermans M, Liesenborghs L, Na M, Björnsdottir H, Zhu X, Jacobsson G, Johansson BR, Geoghegan JA, Foster TJ, Josefsson E, Bylund J, Verhamme P, Jin T. Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation. J Infect Dis. 2016 Jan 1;213(1):139-48. doi: 10.1093/infdis/jiv360.
Larsson DGJ, Svennerholm A-M (2016). The role of antibacterial agents in the development of antibiotic resistance (in Swedish). Läkartidningen 2016;113:D44E.
Marathe NP, Shetty SA, Shouche YS, Larsson DGJ. 2016. Limited bacterial diversity within a treatment plant receiving antibiotic-containing waste from bulk drug production. PloS One 11(11): e0165914. doi:10.1371/journal.pone.0165914.
Munthe C. Antibiotikaresistens och etik. Ord & Bild, (5)64-68, 2016.
Müller V, Karami N, Nyberg LK, Pichler C, Torche Pedreschi PC, Quaderi S, Fritzsche J, Ambjörnsson T, Åhrén C, Westerlund F. Rapid Tracing of Resistance Plasmids in a Nosocomial Outbreak Using Optical DNA Mapping. ACS Infect Dis. 2016 May 13;2(5):322-8. doi: 10.1021/acsinfecdis.6b00017.
Müller V, Rajer F, Frykholm K, Nyberg LK, Quaderi S, Fritzsche J, Kristiansson E, Ambjörnsson T, Sandegren L, Westerlund F. Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping. Sci Rep. 2016 Dec 1;6:37938. doi: 10.1038/srep37938.
Nyberg LK, Quaderi S, Emilsson G, Karami N, Lagerstedt E, Müller V, Noble C, Hammarberg S, Nilsson AN, Sjöberg F, Fritzsche J, Kristiansson E, Sandegren L, Ambjörnsson T, Westerlund F. Rapid identification of intact bacterial resistance plasmids via optical mapping of single DNA molecules. Sci Rep. 2016 Jul 27;6:30410. doi: 10.1038/srep30410.
Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DGJ. (2016). The structure and diversity of human, animal and environmental resistomes. Microbiome. 4:54. doi: 10.1186/s40168-016-0199-5.
Pereira MB, Kristiansson E, Axelsson-Fisk M, HattCI: fast and accurate attC site identification using hidden Markov models. J Comput Biol, 2016 Nov;23(11):891-902. Epub 2016 Jul 18
Runesson J, Shamansurova E, Jacobsson G. Antibiotics are being misused to treat diarrhoeal disease in children in Central Asia. Acta Paediatr. 2016 Dec;105(12):1382-1383. doi: 10.1111/apa.13583. PMID: 27870206.
Rönnerstrand B. Antibiotikaresistens och det kollektiva handlandets problem. Ord & Bild, (5)56-63, 2016.
Rönnerstrand B, Jagers S, Larsson DGJ (2016). Who worries about antibiotic resistance? (In Swedish). Ekvilibrium (Eds. Henrik Oscarsson, Jonas Ohlsson and Maria Solevid). SOM-institutet, University of Gothenburg. ISBN 978-91-89673-35-9.
Salvà-Serra F, Jakobsson HE, Thorell K, Gonzales-Siles L, Hallbäck ET, Jaén-Luchoro D, Boulund F, Sikora P, Karlsson R, Svensson L, Bennasar A, Engstrand L, Kristiansson E, Moore ER. Draft Genome Sequence of Streptococcus gordonii Type Strain CCUG 33482T. Genome Announc. 2016 Mar 24;4(2). pii: e00175-16. doi: 10.1128/genomeA.00175-16.
Skyman E, Lindahl B, Bergbom I, Sjöström HT, Åhrén C. Being Met as marked - patients' experiences of being infected with community-acquired methicillin-resistant Staphylococcus aureus (MRSA). Scand J Caring Sci. 2016 Dec;30(4):813-820. doi: 10.1111/scs.12309.
Swerkersson S, Jodal U, Åhrén C, Sixt R, Stokland E, Hansson S. (2016). Urinary tract infection in infants: the significance of low bacterial count. Pediatr Nephrol. 2016 Feb;31(2):239-45. doi: 10.1007/s00467-015-3199-y.
Svensson J. och C. Verdinelli. Mirakellösningen som blev ett problem. Ord & Bild, (5)36-41, 2016.
Wehrli PM, Angerer TB, Farewell A, Fletcher JS, Gottfries J. Investigating the Role of the Stringent Response in Lipid Modifications during the Stationary Phase in E. coli by Direct Analysis with Time-of-Flight-Secondary Ion Mass Spectrometry. Anal Chem. 2016 Sep 6;88(17):8680-8. doi: 10.1021/acs.analchem.6b01981.
Bengtsson-Palme J, Boulund F, Edström R, Feizi A, Johnning A, Jonsson VA, Karlsson FH, Pal C, Pereira MB, Rehammar A, Sanchez J, Sanli K, Thorell K. Strategies to improve usability and preserve accuracy in biological sequence databases. Proteomics. 2016 Sep;16(18):2454-60. doi: 10.1002/pmic.201600034.
Zaborowska M, Tillander J, Branemark R, Hagberg L, Thomsen P, Trobos M. Biofilm formation and antimicrobial susceptibility of staphylococci and enterococci from osteomyelitis associated with percutaneous orthopaedic implants. J Biomed Mater Res B Appl Biomater. Oct 25 2016.