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Isothiocyanates are important as haptens in contact allergy to chloroprene rubber

Artikel i vetenskaplig tidskrift
Författare A. G. Ramzy
K. Lammintausta
M. Matura
Johanna Bråred Christensson
U. Nilsson
Lina Hagvall
Publicerad i British Journal of Dermatology
Volym 177
Nummer/häfte 2
Sidor 522-530
ISSN 0007-0963
Publiceringsår 2017
Publicerad vid Institutionen för kemi och molekylärbiologi
Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för dermatologi och venereologi
Sidor 522-530
Språk English
Länkar dx.doi.org/10.1111/bjd.15444
Ämnesord dermatitis, thiourea, sensitization, mouse, phenylisothiocyanate, diphenylthiourea, diethylthiourea, sensitivity, derivatives, brace, Dermatology
Ämneskategorier Dermatologi och venereologi

Sammanfattning

Background Contact allergy to chloroprene rubber products is well known. Thiourea compounds are considered the cause of allergy. Diethylthiourea commonly occurs in this type of product and can decompose to the sensitizer ethyl isothiocyanate. Objectives To investigate the clinical importance of degradation products and metabolites from organic thioureas in contact allergy to chloroprene rubber with a focus on isothiocyanates and isocyanates. Methods Patients with contact allergy to diphenylthiourea were patch tested with phenyl isothiocyanate and phenyl isocyanate. Patients with known contact allergy to diethylthiourea were retested with diethylthiourea, while chemical analyses of their chloroprene rubber products were performed. The stability of diethylthiourea, diphenylthiourea and dibutylthiourea in patch-test preparations was investigated. Liquid chromatography/mass spectrometry and solid-phase microextraction/gas chromatography were used for determination of organic thioureas and isothiocyanates. Results All patients allergic to diphenylthiourea reacted to phenyl isothiocyanate, two of eight reacted to phenyl isocyanate and six of eight reacted to diphenylthiourea. Four patients allergic to diethylthiourea reacted at retest; diethylthiourea was detected in all chloroprene rubber samples, with levels of 2-1200 nmol cm(-2). At 35 degrees C, ethyl isothiocyanate was emitted from all samples. Patch-test preparations of diethylthiourea, diphenylthiourea and dibutylthiourea all emitted the corresponding isothiocyanate, with diethylthiourea showing the highest rate of isothiocyanate emission. Conclusions Thiourea compounds are degraded to isothiocyanates, which are generally strong or extreme sensitizers, thus acting as prehaptens. This process occurs in both chloroprene rubber products and patch-test preparations. Positive reactions to phenyl isocyanate indicate cutaneous metabolism, as the only known source of exposure to phenyl isocyanate is through bioactivation of diphenylthiourea.

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