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The N-15 NMR chemical shift in the characterization of weak halogen bonding in solution

Artikel i vetenskaplig tidskrift
Författare Sebastiaan B. Hakkert
Jürgen Gräfenstein
Mate Erdelyi
Publicerad i Faraday Discussions
Volym 203
Sidor 333-346
ISSN 1359-6640
Publiceringsår 2017
Publicerad vid Svenskt NMR-centrum vid Göteborgs universitet
Institutionen för kemi och molekylärbiologi
Sidor 333-346
Språk en
Länkar doi.org/10.1039/c7fd00107j
Ämneskategorier Fysik, Kemi

Sammanfattning

© The Royal Society of Chemistry. We have studied the applicability of 15 N NMR spectroscopy in the characterization of the very weak halogen bonds of nonfluorinated halogen bond donors with a nitrogenous Lewis base in solution. The ability of the technique to detect the relative strength of iodine-, bromine- and chlorine-centered halogen bonds, as well as solvent and substituent effects was evaluated. Whereas computations on the DFT level indicate that 15 N NMR chemical shifts reflect the diamagnetic deshielding associated with the formation of a weak halogen bond, the experimentally observed chemical shift differences were on the edge of detectability due to the low molar fraction of halogen-bonded complexes in solution. The formation of the analogous yet stronger hydrogen bond of phenols have induced approximately ten times larger chemical shift changes, and could be detected and correlated to the electronic properties of substituents of the hydrogen bond donors. Overall, 15 N NMR is shown to be a suitable tool for the characterization of comparably strong secondary interactions in solution, but not sufficiently accurate for the detection of the formation of thermodynamically labile, weak halogen bonded complexes.

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