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Elevated fasting and postprandial C-terminal telopeptide after Roux-en-Y gastric bypass

Artikel i vetenskaplig tidskrift
Författare N. Maghsoodi
J. Alaghband-Zadeh
G. F. Cross
Malin Werling
Lars Fändriks
Neil G. Docherty
Torsten Olbers
T. Dew
R. A. Sherwood
R. P. Vincent
Carel W le Roux
Publicerad i Annals of Clinical Biochemistry
Volym 54
Nummer/häfte 4
Sidor 495-500
ISSN 0004-5632
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för gastrokirurgisk forskning och utbildning
Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning
Sidor 495-500
Språk English
Länkar doi.org/10.1177/0004563216667964
Ämnesord Roux-en-Y gastric bypass, parathyroid hormone, bile acids, C-terminal telopeptide, bone-mineral density, bariatric surgery, bile-acids, vitamin-d, adiponectin, metabolism, resorption, glucose, obesity, Medical Laboratory Technology
Ämneskategorier Gastroenterologi

Sammanfattning

Background Roux-en-Y gastric bypass increases circulating bile acid concentrations, known mediators of postprandial suppression of markers of bone resorption. Long-term data, however, indicate that Roux-en-Y gastric bypass confers an increased risk of bone loss on recipients. Methods Thirty-six obese individuals, median age 44 (26-64) with median body mass index at baseline of 42.5 (40.4-46) were studied before and 15 months after Roux-en-Y gastric bypass. After an overnight fast, patients received a 400kcal mixed meal. Blood samples were collected premeal then at 30-min periods for 120min. Pre and postmeal samples were analysed for total bile acids, parathyroid hormone and C-terminal telopeptide. Results Body weight loss post Roux-en-Y gastric bypass was associated with a median 4.9-fold increase in peak postprandial total bile acid concentration, and a median 2.4-fold increase in cumulative food evoked bile acid response. Median fasting parathyroid hormone, postprandial reduction in parathyroid hormone and total parathyroid hormone release over 120min remained unchanged after surgery. After surgery, median fasting C-terminal telopeptide increased 2.3-fold, peak postprandial concentrations increased 3.8-fold and total release was increased 1.9-fold. Conclusions Fasting and postprandial total bile acids and C-terminal telopeptide are increased above reference range after Roux-en-Y gastric bypass. These changes occur in spite of improved vitamin D status with supplementation. These results suggest that post-Roux-en-Y gastric bypass increases in total bile acids do not effectively oppose an ongoing resorptive signal operative along the gut-bone axis. Serial measurement of C-terminal telopeptide may be of value as a risk marker for long-term skeletal pathology in patients post Roux-en-Y gastric bypass.

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